|本期目录/Table of Contents|

[1]陈园,赵淑娟.微生物莽草酸代谢途径的研究进展[J].江苏农业科学,2019,47(07):19-23.
 Chen Yuan,et al.Research progress of microbial shikimic acid metabolic pathway[J].Jiangsu Agricultural Sciences,2019,47(07):19-23.
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微生物莽草酸代谢途径的研究进展(PDF)
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第47卷
期数:
2019年第07期
页码:
19-23
栏目:
专论与综述
出版日期:
2019-05-10

文章信息/Info

Title:
Research progress of microbial shikimic acid metabolic pathway
作者:
陈园 赵淑娟
上海中医药大学中药研究所/中药新资源与品质评价国家中医药管理局重点研究室/中药标准化教育部重点实验室/
上海市复方中药重点实验室,上海 201203
Author(s):
Chen Yuanet al
关键词:
莽草酸代谢途径基因改造关键酶基因辅因子
Keywords:
-
分类号:
Q945.1
DOI:
-
文献标志码:
A
摘要:
莽草酸是莽草酸代谢途径的中间产物,是合成手型药物的关键原料,也是合成芳香族类氨基酸(L-苯丙氨酸、L-酪氨酸、L-色氨酸)、泛醌、叶酸、维生素K2等芳香族化合物的关键中间体。通过基因改造微生物莽草酸代谢途径,可以使其大量积累莽草酸,进而为生物体内合成芳香族氨基酸奠定基础。本文综述了莽草酸代谢途径在重组大肠杆菌中的生物合成途径的研究进展,分析了莽草酸合成过程中关键酶基因改造对莽草酸积累的影响、辅因子再生对目的产物的影响,还讨论了减少莽草酸工程菌代谢副产物产生量的措施。随着代谢工程技术和合成生物学技术的发展,通过基因技术定向改造代谢途径,构建理想的高产菌株已经成为研究的新热点。
Abstract:
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参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2017-11-10
基金项目:国家自然科学基金(编号:81673540);上海市自然科学基金(编号:16ZR1434100)。
作者简介:陈园(1992—),男,河南驻马店人,硕士研究生,要从事中药生物技术方面的研究。E-mail:chen1992yuan@sina.com。
通信作者:赵淑娟,博士,研究员,主要从事中药生物技术方面的研究。E-mail:zhaoshujuan@126.com。
更新日期/Last Update: 2019-04-05