|本期目录/Table of Contents|

[1]王亚磊,茆达干,孟春花,等.PRRSV非结构蛋白与病毒逃逸宿主免疫反应的机制[J].江苏农业科学,2014,42(05):165-167.
　Wang Yalei,et al.Mechanism of PRRSV escaping its host immune response through non-structural proteins of PRRSV[J].Jiangsu Agricultural Sciences,2014,42(05):165-167.
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第42卷
期数:
2014年05期
页码:
165-167
栏目:
畜牧兽医
出版日期:
2014-05-25

文章信息/Info

Title:
Mechanism of PRRSV escaping its host immune response through non-structural proteins of PRRSV
作者:
王亚磊1; 2;  茆达干1;  孟春花2; 3;  李静心2; 3;  曹少先2; 3
1.南京农业大学动物科技学院，江苏南京 210095； 2.江苏省农业科学院畜牧研究所，江苏南京 210014；3.江苏省农业科学院动物品种改良和繁育重点实验室，江苏南京 210014
Author(s):
Wang Yalei; et al
关键词:
猪繁殖与呼吸综合征病毒; 非结构蛋白; Ⅰ型干扰素; 免疫逃逸
Keywords:
-
分类号:
A
DOI:
-
文献标志码:
S852.65+1
摘要:
猪繁殖与呼吸综合征病毒（PRRSV）是当今养猪业面临的最严重的病毒病原体之一。病毒在猪群中持久存在给控制和消除该疾病带来了挑战。其持久存在的生理基础包括逃逸宿主的先天性免疫和适应性免疫应答，而抑制Ⅰ型干扰素的产生是主要途径。本文主要阐述PRRSV通过非结构蛋白（NSP）干扰RIG-Ⅰ/MDA5等信号通路，抑制Ⅰ型干扰素产生，逃避宿主免疫反应的机制。
Abstract:
-

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备注/Memo

备注/Memo:
收稿日期：2013-08-29
基金项目：江苏省农业科技自主自主创新资金［编号：CX(12)2034］；国家自然科学基金（编号：30972075）。
作者简介：王亚磊（1989—），男，河北邯郸人，硕士研究生，主要从事猪蓝耳病抗性遗传研究。E-mail：2012105024@njau.edu.cn。
通信作者：曹少先，博士，研究员。Tel：（025）84390352；E-mail：caoshaoxian@163.com。
更新日期/Last Update: 2014-05-25