|本期目录/Table of Contents|

[1]周超平,胡传圣,孟益聪,等.组蛋白macroH2A在G1/S和M期的分布差异[J].江苏农业科学,2015,43(06):28-31.
 Zhou Chaoping,et al.Redistribution of histone variant macroH2A between G1/S and mitotic phase[J].Jiangsu Agricultural Sciences,2015,43(06):28-31.
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组蛋白macroH2A在G1/S和M期的分布差异(PDF)
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第43卷
期数:
2015年06期
页码:
28-31
栏目:
生物技术
出版日期:
2015-06-25

文章信息/Info

Title:
Redistribution of histone variant macroH2A between G1/S and mitotic phase
作者:
周超平1 胡传圣2 孟益聪2 程酩2 李鑫辉2
1.上海交通大学系统生物医学研究院,上海 200240; 2.上海交通大学生物医学工程学院,上海 200240
Author(s):
Zhou Chaopinget al
关键词:
macroH2AH2A组蛋白变体染色体转录分布
Keywords:
-
分类号:
Q51;Q71;TQ936.21+6
DOI:
-
文献标志码:
A
摘要:
组蛋白macroH2A(mH2A)具有独特的结构和丰富的亚型,不但具有转录活化和抑制功能,还作用于细胞增殖和肿瘤发生等过程。采用同步化培养的NIH/3T3细胞,分别提取G1/S和M期的组蛋白H2A及mH2A,通过免疫荧光和Western blot从定性和定量2方面分析mH2A的分布情况。结果显示,在总含量保持不变的情况下,mH2A在 G1/S 和M期的分布有显著差异,从G1/S期进入M期,mH2A在染色体上的分布出现约30%的增长。结果表明,mH2A在细胞周期内的分布有显著差异,很可能与转录激活有关。
Abstract:
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参考文献/References:

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相似文献/References:

[1]时小艳,于建宁,吴宝江,等.小鼠原始生殖细胞迁移过程中macroH2A的表达[J].江苏农业科学,2013,41(04):193.

备注/Memo

备注/Memo:
收稿日期:2015-04-15
基金项目:国家自然科学基金(编号:91229108)。
作者简介:周超平(1990—),女,江苏张家港人,硕士研究生,研究方向为染色体结构和组蛋白功能。Tel:(021)34206632;E-mail:dancychou@163.com。
通信作者:李鑫辉,博士,助理研究员,主要从事分子生物学研究。Tel:(021)34206632;E-mail:xhli@sjtu.edu.cn。
更新日期/Last Update: 2015-06-25