|本期目录/Table of Contents|

[1]卢劲晔,顾蓓蓓,马卉,等.视黄醇对大肠杆菌诱导的大鼠乳腺上皮细胞NF-κB信号通路的抑制作用[J].江苏农业科学,2019,47(06):35-38.
 Lu Jingye,et al.Inhibitory of retinol on Escherichia coli-induced NF-κB signaling pathway in rat mammary epithelial cells[J].Jiangsu Agricultural Sciences,2019,47(06):35-38.
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视黄醇对大肠杆菌诱导的大鼠乳腺上皮细胞
NF-κB信号通路的抑制作用
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第47卷
期数:
2019年第06期
页码:
35-38
栏目:
生物技术
出版日期:
2019-04-05

文章信息/Info

Title:
Inhibitory of retinol on Escherichia coli-induced NF-κB signaling pathway in rat mammary epithelial cells
作者:
卢劲晔1 顾蓓蓓12 马卉2 卢炜1 刘静1
1.江苏农牧科技职业学院,江苏泰州 225300; 2.泰州出入境检验检疫局,江苏泰州 225300
Author(s):
Lu Jingyeet al
关键词:
视黄醇乳腺上皮细胞大鼠NF-κB信号通路
Keywords:
-
分类号:
S858.237.2+6
DOI:
-
文献标志码:
A
摘要:
为探讨视黄醇对大肠杆菌诱发的大鼠乳腺上皮细胞炎症反应的影响,原代培养大鼠乳腺上皮细胞,试验组预先经视黄醇处理24 h后,对照组和试验组分别经大肠杆菌处理30 min和60 min,收集细胞和上清液。结果显示,大肠杆菌诱发能显著提高TLR4和NF-κB表达,进而促进促炎性细胞因子TNF-α、IL-1β的释放以及炎性介质iNOS(诱导型-氧化氮合酶)的表达。视黄醇处理能抑制NF-κB表达,进而降低炎性细胞因子和炎性介质的释放和表达,从而达到保护乳腺上皮细胞的作用。
Abstract:
-

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2017-11-02
基金项目:江苏省自然科学基金面上研究项目(编号:BK20151354);江苏农牧科技职业学院科研课题(编号:NSF201609);江苏省现代畜牧与新兽药工程技术中心开放课题(编号:TGC2XKF1402)。
作者简介:卢劲晔(1983—),男,江苏扬州人,博士,讲师,主要从事乳腺炎的营养免疫调节机制研究。E-mail:leopardleo@163.com。
更新日期/Last Update: 2019-03-20