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[1]计文,陶权丹,王时超,等.SMC蛋白结构和功能的研究进展[J].江苏农业科学,2019,47(10):32-37.
　Ji Wen,et al.Research progress of structure and function of SMC protein[J].Jiangsu Agricultural Sciences,2019,47(10):32-37.
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SMC蛋白结构和功能的研究进展(PDF)
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第47卷
期数:
2019年第10期
页码:
32-37
栏目:
专论与综述
出版日期:
2019-06-12

文章信息/Info

Title:
Research progress of structure and function of SMC protein
作者:
计文;  陶权丹;  王时超;  华杰;  刘康伟;  张建祥;  于梅梅;  于恒秀
扬州大学农学院/江苏省作物遗传生理重点实验室/植物功能基因组学教育部重点实验室/江苏省作物基因组学和分子育种
重点实验室/江苏省粮食作物现代产业技术协同创新中心，江苏扬州 225009
Author(s):
Ji Wen; et al
关键词:
染色体结构维持蛋白; 凝聚蛋白; 黏结蛋白; SMC5-SMC6复合体
Keywords:
-
分类号:
S188
DOI:
-
文献标志码:
A
摘要:
染色体不仅仅由DNA构成，还包含一些使染色体能具有特定形态特征以及在基因表达和基因组稳定性中起作用的蛋白。而使染色体能具有特定形态特征的首要物质就是染色体结构维持蛋白(structural maintenance of chromosomes，SMC)复合体。SMC复合体包含凝聚蛋白(condensin)、黏结蛋白(cohesin)和SMC5-SMC6复合体，是染色体的重要组分。SMC蛋白的表达依赖于ATP的水解以及DNA的拓扑作用。SMC复合体参与了多重染色体行为，其中尤为显著的是染色体集缩和姐妹染色单体的黏着。此外，SMC复合体在DNA修复中也有重要的作用。近年来，随着分子生物学研究技术的发展，对该类复合体的结构、功能及作用机制等方面已有较多研究并取得一些重要进展，本文对SMC蛋白结构和功能的研究进展做一综述。
Abstract:
-

参考文献/References:

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相似文献/References:

备注/Memo

备注/Memo:
收稿日期：2019-01-24
基金项目：国家自然科学基金(编号：31872859)；江苏省扬州市科技计划(编号：YZ2017059)；江苏高校优势学科建设工程资助项目。
作者简介：计文(1994—)，男，江苏扬州人，硕士研究生，主要从事水稻作物遗传育种研究。E-mail：1902596416@qq.com。
通信作者：于恒秀，博士，教授，主要从事水稻作物遗传育种研究。Tel：(0514)87979304；E-mail：hxyu@yzu.edu.cn。
更新日期/Last Update: 2019-05-20