|本期目录/Table of Contents|

[1]李雷,王悦,李晓悦,等.哈萨克羊骨骼肌差异表达基因的筛选及功能分析[J].江苏农业科学,2023,51(18):62-67.
　Li Lei,et al.Screening and functional analysis of differentially expressed genes in skeletal muscle of Kazakh sheep[J].Jiangsu Agricultural Sciences,2023,51(18):62-67.
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哈萨克羊骨骼肌差异表达基因的筛选及功能分析(PDF)
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第51卷
期数:
2023年第18期
页码:
62-67
栏目:
生物技术
出版日期:
2023-09-20

文章信息/Info

Title:
Screening and functional analysis of differentially expressed genes in skeletal muscle of Kazakh sheep
作者:
李雷; 王悦; 李晓悦; 刘开平; 戴继鸿; 李村院; 胡圣伟
石河子大学生命科学学院，新疆石河子 832003
Author(s):
Li Lei; et al
关键词:
绵羊; 骨骼肌; 转录组; 胎儿期; 成年期
Keywords:
-
分类号:
S813.3；S826.2
DOI:
-
文献标志码:
A
摘要:
骨骼肌是家畜重要的器官，直接影响家畜的产肉量和品质。骨骼肌的生长取决于胎儿期纤维的数量和成年期的肥大程度，因此，研究骨骼肌胎儿期发育时的调控基因有助于改善家畜的生产性能。利用RNA-seq技术分析胎儿期和成年期哈萨克羊骨骼肌的转录组数据，筛选出2 692个差异表达基因。对差异表达的基因使用GO和KEGG富集分析发现，被显著富集的包括细胞周期、钙信号通路、cGMP-PKG信号通路、p53信号通路、ECM-受体相互作用、PI3K-Akt信号通路等在调控骨骼肌生长发育中发挥重要功能的信号通路。且本研究筛选了5个与肌肉发育相关的候选基因：POSTN、MYL4、ARHGAP36、BCAT1和FBN2。不仅为绵羊的分子选育提供科学依据，并且为肌肉生长机制的深入研究、提高绵羊生产性能打下良好基础。
Abstract:
-

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备注/Memo

备注/Memo:
收稿日期：2022-12-19
基金项目：新疆生产建设兵团科技攻关计划项目(编号：2019AB034、2021CB033)。
作者简介：李雷(1995—)，男，山西长治人，硕士，研究方向为动物学。E-mail：2390235140@qq.com。
通信作者：李村院，博士，研究方向为动物遗传育种与繁殖，E-mail：3180869341@qq.com；胡圣伟，博士，教授，研究方向为肠道微生物功能基因挖掘，E-mail：hushengwei@163.com。
更新日期/Last Update: 2023-09-20