|本期目录/Table of Contents|

[1]庄娟,单群,张子峰,等.BDE-47对小鼠肝肾和脑氧化应激及炎症反应的影响[J].江苏农业科学,2019,47(19):302-306.
 Zhuang Juan,et al.Effects of BDE-47 on oxidative stress and inflammation of mouse liver,kidney and brain[J].Jiangsu Agricultural Sciences,2019,47(19):302-306.
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BDE-47对小鼠肝肾和脑氧化应激及炎症反应的影响(PDF)
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第47卷
期数:
2019年第19期
页码:
302-306
栏目:
资源与环境
出版日期:
2019-11-04

文章信息/Info

Title:
Effects of BDE-47 on oxidative stress and inflammation of mouse liver,kidney and brain
作者:
庄娟1 单群2 张子峰2 徐建明1 郑元林2
庄娟1, 单群2, 张子峰2, 徐建明1, 郑元林2
Author(s):
Zhuang Juanet al
关键词:
BDE-47肝脏肾脏脏器系数氧化应激炎症反应基因表达
Keywords:
-
分类号:
X174
DOI:
-
文献标志码:
A
摘要:
主要探讨了持续性有机环境污染物2,2′,4,4′-四溴联苯醚(2,2′,4,4′-tetrabromodiphenyl ether,BDE-47)对小鼠肝肾和脑组织氧化应激及炎症反应的毒性效应。将C57BL/6J小鼠分为4组,即对照组小鼠灌胃玉米油,低剂量组、中剂量组和高剂量组为对小鼠分别灌胃10、20、40 mg/kg BDE-47,每天处理1次,4、6、8周后称肝肾和脑组织湿质量并计算脏器系数,测定染毒8周后的小鼠肝肾和脑组织活性氧水平及炎症因子IL-6和TNF-α的表达情况。结果发现,BDE-47可造成肝脏脏器系数增大,肾脏和脑脏器系数减小,BDE-47可促进肝肾和脑组织活性氧堆积,炎症因子IL-6和TNF-α表达增强,这可能是造成这些组织损伤的重要机制。
Abstract:
-

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2018-07-09
基金项目:国家自然科学基金(编号:81171012、81570531、31200873);江苏高校品牌专业建设工程(编号:PPZY2015A018);江苏省高校自然科学基金(编号:18KJB330001)。
作者简介:庄娟(1977—),女,江苏南通人,博士,讲师,主要从事环境毒理研究。E-mail:dajiangsky@163.com。
通信作者:郑元林,博士,教授,主要从事抗衰老的分子生物学机制研究。E-mail:zhengyl@jsnu.edu.cn。
更新日期/Last Update: 2019-10-05