|本期目录/Table of Contents|

[1]耿宁宁,戴竹青,牛丽影,等.膳食纤维调节肠道微生物对机体健康的影响研究进展[J].江苏农业科学,2021,49(7):51-56.
 Geng Ningning,et al.Effects of dietary fiber regulating human intestinal microflora on body health:a review[J].Jiangsu Agricultural Sciences,2021,49(7):51-56.
点击复制

膳食纤维调节肠道微生物对机体健康的影响研究进展(PDF)
分享到:

《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第49卷
期数:
2021年第7期
页码:
51-56
栏目:
专论与综述
出版日期:
2021-04-05

文章信息/Info

Title:
Effects of dietary fiber regulating human intestinal microflora on body health:a review
作者:
耿宁宁12戴竹青2牛丽影2刘春菊2吴刚3宋江峰12
1.江苏大学食品与生物工程学院,江苏镇江 212013; 2.江苏省农业科学院农产品加工研究所,江苏南京 210014;3.江苏嘉安食品有限公司,江苏南通 226363
Author(s):
Geng Ningninget al
关键词:
膳食纤维肠道微生物短链脂肪酸机体健康糖尿病心血管疾病
Keywords:
-
分类号:
TS201.4
DOI:
-
文献标志码:
A
摘要:
膳食纤维具有独特的理化性质和广泛功能特性,膳食纤维及其发酵产物短链脂肪酸(short chain fatty acids,简称SAFCs)可选择性地改变肠道微生物的组成,进而起到预防糖尿病、降低血糖血压、控制体质量、提高免疫力、降低炎性因子表达水平和患心脑血管疾病风险的作用效果。在查阅大量文献的基础上对膳食纤维的分类、理化性质、功能特性以及影响机体健康的机制进行了综述并对未来的研究进行展望。
Abstract:
-

参考文献/References:

[1]Erkkil A T,Lichtenstein A H. Fiber and cardiovascular disease risk:how strong is the evidence ?[J]. The Journal of Cardiovascular Nursing,2006,21(1):3-8.
[2]Abdul-Hamid A,Luan Y S. Functional properties of dietary fibre prepared from defatted rice bran[J]. Food Chemistry,2000,68(1):15-19.
[3]Eastwood M,Kritchevsky D. Dietary fiber:how did we get where we are ?[J]. Annual Review of Nutrition,2005,25(1):1-8.
[4]Jonsson A L,Backhed F. Role of gut microbiota in atherosclerosis[J]. Nature Reviews Cardiology,2017,14(2):79-87.
[5]Scharlau D,Borowicki A,Habermann N,et al. Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre[J]. Mutation Research,2009,682(1):39-53.
[6]Payne A,Zihler A,Chassard C,et al. Advances and perspectives in in vitro human gut fermentation modeling[J]. Trends in Biotechnology,2012,30(1):17-25.
[7]Verspreet J,Damen B,Broekaert W F,et al. A critical look at prebiotics within the dietary fiber concept[J]. Annual Review of Food Science and Technology,2016,7:167-190.
[8]Campos-Vega R,Dave Oomah B,Vergara-Castaeda H A. In vivo and in vitro studies on dietary fiber and gut health[M]//Hosseinian F,Dave Oomah B,Campos-Vega R. Dietary fiber functionality in food and nutraceuticals:from plant to gut. West Sussex:John Wiley & Sons Ltd,2017.
[9]Chuang S C,Norat T,Murphy N,et al. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort[J]. The American Journal of Clinical Nutrition,2012,96(1):164-174.
[10]Anderson J W,Baird P,Davis R J,et al. Health benefits of dietary fiber[J]. Nutrition Reviews,2009,67(4):188-205.
[11]Dhingra D,Michael M,Rajput H,et al. Dietary fibre in foods:a review[J]. Journal of Food Science and Technology-Mysore,2012,49(3):255-266.
[12]Wang L,Xu H G,Yuan F,et al. Physicochemical characterization of five types of citrus dietary fibers[J]. Biocatalysis and Agricultural Biotechnology,2015,4(2):250-258.
[13]Ajila C M,Bhat S G,Prasada R U. Valuable components of raw and ripe peels from two Indian mango varieties[J]. Food Chemistry,2007,102(4):1006-1011.
[14]Elleuch M,Bedigian D,Roiseux O,et al. Dietary fibre and fibre-rich by-products of food processing:characterisation,technological functionality and commercial applications:a review[J]. Food Chemistry,2011,124(2):411-421.
[15]蔡松铃,刘琳,战倩,等. 膳食纤维的黏度特性及其生理功能研究进展[J]. 食品科学,2020,41(3):224-231.
[16]Theuwissen E,Mensink R P. Water-soluble dietary fibers and cardiovascular disease[J]. Physiology & Behavior,2008,94(2):285-292.
[17]Li H,Yang C H,Kim S H. Research on the facilitation of dietary fiber to body digestive function[J]. Advance Journal of Food Science and Technology,2015,9(1):48-51.
[18]Dongowski G,Huth M,Gebhardt E,et al. Dietary fiber-rich barley products beneficially affect the intestinal tract of rats[J]. The Journal of Nutrition,2002,132(12):3704-3714.
[19]Macfarlane S,Macfarlane G T,Cummings J H. Review article:prebiotics in the gastrointestinal tract[J]. Alimentary Pharmacology and Therapeutics,2006,24(5):701-714.
[20]Costello S P,Soo W,Bryant R V,et al. Systematic review with meta-analysis:faecal microbiota transplantation for the induction of remission for active ulcerative colitis[J]. Alimentary Pharmacology and Therapeutics,2017,46(3):213-224.
[21]Cui J,Lian Y,Zhao C,et al. Dietary fibers from fruits and vegetables and their health benefits via modulation of gut microbiota[J]. Comprehensive Reviews in Food Science and Food Safety,2019,18(5):1514-1532.
[22]Shan M,Gentile M,Yeiser J R,et al. Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals[J]. Science,2013,342(6157):447-453.
[23]Morowitz M J,di Caro V,Pang D,et al. Dietary supplementation with nonfermentable fiber alters the gut microbiota and confers protection in murine models of sepsis[J]. Critical Care Medicine,2017,45(5):516-523.
[24]Barker N. Adult intestinal stem cells:critical drivers of epithelial homeostasis and regeneration[J]. Nature Reviews Molecular Cell Biology,2014,15(1):19-33.
[25]Kelly C J,Zheng L,Campbell E L,et al. Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function[J]. Cell Host and Microbe,2015,17(5):662-671.
[26]Fu Z,Gilbert E R,Liu D M. Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes[J]. Current Diabetes Reviews,2013,9(1):25-53.
[27]Delzenne N M,Cani P D,Everard A,et al. Gut microorganisms as promising targets for the management of type 2 diabetes[J]. Diabetologia,2015,58(10):2206-2217.
[28]Schulze M B,Liu S,Rimm E B,et al. Glycemic index,glycemic load,and dietary fiber intake and incidence of type 2 diabetes in younger and middle-aged women[J]. The American Journal of Clinical Nutrition,2004,80(2):348-356.
[29]Mcrae M P. Dietary fiber intake and type 2 diabetes mellitus:an umbrella review of meta-analyses[J]. Journal of Chiropractic Medicine,2018,17(1):44-53.
[30]Davison K M,Temple N J. Cereal fiber,fruit fiber,and type 2 diabetes:explaining the paradox[J]. Journal of Diabetes and Its Complications,2018,32(2):240-245.
[31]Chambers E S,Viardot A,Psichas A,et al. Effects of targeted delivery of propionate to the human colon on appetite regulation,body weight maintenance and adiposity in overweight adults[J]. Gut,2015,64(11):1744-1754.
[32]Grasset E,Puel A,Charpentier J,et al. A specific gut microbiota dysbiosis of type 2 diabetic mice induces GLP-1 resistance through an enteric NO-dependent and gut-brain axis mechanism[J]. Cell metabolism,2017,25(5):1075-1090.
[33]Mandaliya D K,Seshadri S. Short chain fatty acids,pancreatic dysfunction and type 2 diabetes[J]. Pancreatology,2019,19(4):617-622.
[34]Lin H V,Frassetto A,Kowalik Jr E J,et al. Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms[J]. PLoS One,2012,7(4):e35240.
[35]Perfetti R,Hui H. The role of GLP-1 in the life and death of pancreatic beta cells[J]. Hormone and Metabolic Research,2004,36(11/12):804-810.
[36]Li Y Z,Cao X M,Li L X,et al. β-Cell Pdx1 expression is essential for the glucoregulatory,proliferative,and cytoprotective actions of glucagon-like peptide-1[J]. Diabetes,2005,54(2):482-491.
[37]Talchai C,Xuan S H,Lin H V,et al. Pancreatic β cell dedifferentiation as a mechanism of diabetic β cell failure[J]. Cell,2012,150(6):1223-1234.
[38]Kitamura T. The role of FOXO1 in β-cell failure and type 2 diabetes mellitus[J]. Nature Reviews Endocrinology,2013,9(10):615-623.
[39]Li L,Ren L L,Qi H,et al. Combination of GLP-1 and sodium butyrate promote differentiation of pancreatic progenitor cells into insulin-producing cells[J]. Tissue and Cell,2008,40(6):437-445.
[40]Goicoa S,Alvarez S,Ricordi C,et al. Sodium butyrate activates genes of early pancreatic development in embryonic stem cells[J]. Cloning and Stem Cells,2006,8(3):140-149.
[41]Pedersen H K,Gudmundsdottir V,Nielsen H B,et al. Human gut microbes impact host serum metabolome and insulin sensitivity[J]. Nature,2016,535(7612):376.
[42]Hooper O V,Littman D R,Macpherson A J. Interactions between the microbiota and the immune system[J]. Science,2012,336(6086):1268-1273.
[43]Vogt L,Ramasamy U,Meyer D,et al. Immune modulation by different types of β2→1-fructans is toll-like receptor dependent[J]. PLoS One,2013,8(7):e68367.
[44]Albers R,Bourdet-Sicard R,Braun D,et al. Monitoring immune modulation by nutrition in the general population:identifying and substantiating effects on human health[J]. The British Journal of Nutrition,2013,110 (Suppl 2):1-30.
[45]Chawla R,Patil G R. Soluble dietary fiber[J]. Comprehensive Reviews in Food Science and Food Safety,2010,9(2):178-196.
[46]Vinolo M R,Rodrigues H G,Nachbar R T,et al. Regulation of inflammation by short chain fatty acids[J]. Nutrients,2011,3(10):858-876.
[47]Macia L,Tan J,Vieira A T,et al. Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome[J]. Nature communications,2015,6:6734.
[48]Meijer K,de Vos P,Priebe M G. Butyrate and other short-chain fatty acids as modulators of immunity:what relevance for health ?[J]. Current Opinion in Clinical Nutrition and Metabolic Care,2010,13(6):715-721.
[49]Singh N,Gurav A,Sivaprakasam S,et al. Activation of Gpr109a,receptor for niacin and the commensal metabolite butyrate,suppresses colonic inflammation and carcinogenesis[J]. Immunity,2014,40(1):128-139.
[50]Kalala G,Kambashi B,Everaert N,et al. Characterization of fructans and dietary fibre profiles in raw and steamed vegetables[J]. International Journal of Food Sciences and Nutrition,2018,69(6):682-689.
[51]Raso G M,Simeoli R,Russo R A,et al. Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet[J]. PLoS One,2013,8(7):e68626.
[52]Morrison D J,Preston T. Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism[J]. Gut Microbes,2016,7(3):189-200.
[53]胡盛寿,高润霖,刘力生,等. 《中国心血管病报告2018》概要[J]. 中国循环杂志,2019,34(3):209-220.
[54]Natarajan N,Hori D,Flavahan S,et al. Microbial short chain fatty acid metabolites lower blood pressure via endothelial G protein-coupled receptor 41[J]. Physiological Genomics,2016,48(11):826-834.
[55]Sender R,Fuchs S,Milo R. Are we really vastly outnumbered ? revisiting the ratio of bacterial to host cells in humans[J]. Cell,2016,164(3):337-340.
[56]Montandon S,Jornayvaz F R. Effects of antidiabetic drugs on gut microbiota composition[J]. Genes,2017,8(10):250.
[57]OHara A M,Shanahan F. The gut flora as a forgotten organ[J]. EMBO Reports,2006,7(1):688-693.
[58]Weickert M,Pfeiffer A F. Metabolic effects of dietary fiber consumption and prevention of diabetes[J]. The Journal of Nutrition,2008,138(3):439-442.
[59]Wu G D,Compher C,Chen E Z,et al. Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production[J]. Gut,2016,65(1):63-72.
[60]Kovatcheva-Datchary P,Nilsson A,Akrami R,et al. Dietary fiber-induced improvement in glucose metabolism is associated with increased abundance of Prevotella[J]. Cell Metabolism,2015,22(6):971-982.
[61]Sato J,Kanazawa A,Ikeda F,et al. Gut dysbiosis and detection of “live gut bacteria” in blood of Japanese patients with type 2 diabetes[J]. Diabetes Care,2014,37(8):2343-2350.
[62]Canfora E E,Jocken J W,Blaak E E. Short-chain fatty acids in control of body weight and insulin sensitivity[J]. Nature Reviews Endocrinology,2015,11(10):577-591.
[63]Zou J,Chassaing B,Singh V,et al. Fiber-Mediated nourishment of gut microbiota protects against diet-induced obesity by restoring IL-22-mediated colonic health[J]. Cell Host & Microbe,2018,23(1):41-53.
[64]Walker A W,Ince J,Duncan S H,et al. Dominant and diet-responsive groups of bacteria within the human colonic microbiota[J]. The ISME Journal,2011,5(2):220-230.
[65]Drew J E,Reichardt N,Williams L M,et al. Dietary fibers inhibit obesity in mice,but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition[J]. Scientific reports,2018,8(1):1-11.

相似文献/References:

[1]孙勇,曹小迎,蒋继宏,等.华北大黑鳃金龟幼虫肠道菌的分离及对农药的降解[J].江苏农业科学,2016,44(02):151.
 Sun Yong,et al.Isolation and pesticides degradation of intestinal microflora from Holotrichia oblita larvae[J].Jiangsu Agricultural Sciences,2016,44(7):151.
[2]冯飞斐,王一丁.应用Illumina高通量测序技术分析中华真地鳖肠道微生物多样性[J].江苏农业科学,2018,46(04):167.
 Feng Feifei,et al.Study on diversity of intestinal microbiota in Eupolyphage sinensis Walker using Illumina high-throughput sequencing system[J].Jiangsu Agricultural Sciences,2018,46(7):167.
[3]刘均,刘雅丽,夏兵.茶多酚对动物健康的保护作用研究进展[J].江苏农业科学,2018,46(12):14.
 Liu Jun,et al.Research progress of protective effect of tea polyphenols on animal health[J].Jiangsu Agricultural Sciences,2018,46(7):14.
[4]李小义,张效平,赵凤,等.鲟鱼肠道微生物多样性的研究[J].江苏农业科学,2018,46(24):164.
 Li Xiaoyi,et al.Study on diversity of gut microbiota of sturgeon[J].Jiangsu Agricultural Sciences,2018,46(7):164.
[5]韩晓云,刘鹏,王震,等.核桃青皮提取液在腹泻小鼠体内的抑菌效果[J].江苏农业科学,2019,47(24):162.
 Han Xiaoyun,et al.Antimicrobial activity of extracts from walnut peel to mice in vivo[J].Jiangsu Agricultural Sciences,2019,47(7):162.
[6]黄薇,刘兰英,罗土炎,等.鳗鲡肠道微生物抗性基因组成特征的初步分析[J].江苏农业科学,2020,48(21):57.
 Huang Wei,et al.Preliminary analysis of antibiotic resistance genes in eel intestinal microbiota[J].Jiangsu Agricultural Sciences,2020,48(7):57.
[7]杨晓志,顾文婕,吉俊玲,等.五味子对产蛋期藏鸡肠道微生物菌群的影响[J].江苏农业科学,2023,51(4):180.
 Yang Xiaozhi,et al.Impacts of Schisandra chinensis on intestinal microbiota in Tibetan chicken during egg-laying period[J].Jiangsu Agricultural Sciences,2023,51(7):180.
[8]岑明珠,张宇煊,郑朝军,等.肠道微生物对鸡免疫功能的影响综述[J].江苏农业科学,2023,51(11):10.
 Cen Mingzhu,et al.Influence of gut microbes on immune function of chickens: a review[J].Jiangsu Agricultural Sciences,2023,51(7):10.
[9]易春燕,刘旭,王燕平,等.草地贪夜蛾与黏虫肠道微生物的多样性分析[J].江苏农业科学,2024,52(5):140.
 Yi Chunyan,et al.Analysis of gut microbiota diversity of Spodoptera frugiperda and Mythimna separate[J].Jiangsu Agricultural Sciences,2024,52(7):140.

备注/Memo

备注/Memo:
收稿日期:2020-08-03
基金项目:江苏省重点研发计划(现代农业)项目(编号:BE2019324)。
作者简介:耿宁宁 (1996—),女,河南许昌人,硕士研究生,主要从事果蔬加工研究。E-mail:1584940455@qq.com。
通信作者:宋江峰,博士,副研究员,湖北随州人,主要从事果蔬加工与品质功能调控研究。E-mail:songjiangfeng102@163.com。
更新日期/Last Update: 2021-04-05