|本期目录/Table of Contents|

[1]岑明珠,张宇煊,郑朝军,等.肠道微生物对鸡免疫功能的影响综述[J].江苏农业科学,2023,51(11):10-19.
　Cen Mingzhu,et al.Influence of gut microbes on immune function of chickens： a review[J].Jiangsu Agricultural Sciences,2023,51(11):10-19.
点击复制

肠道微生物对鸡免疫功能的影响综述(PDF)
分享到：

《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第51卷
期数:
2023年第11期
页码:
10-19
栏目:
专论与综述
出版日期:
2023-06-05

文章信息/Info

Title:
Influence of gut microbes on immune function of chickens： a review
作者:
岑明珠; 张宇煊; 郑朝军; 欧建存; 丘婷; 林树茂; 张辉华
佛山科学技术学院，广东佛山 528200
Author(s):
Cen Mingzhu; et al
关键词:
鸡; 肠道微生物; 肠道免疫系统; 免疫细胞; 代谢产物
Keywords:
-
分类号:
S831.5
DOI:
-
文献标志码:
A
摘要:
鸡肠道微生物群是一个庞大又复杂的生态系统，其内的基因可能比宿主自身多100倍，鸡肠道微生物在机体内参与营养物质的吸收与消化，维持肠道内稳态有利于机体健康生长，同时也是维持机体内环境稳态的先天性防御屏障。由此可见，鸡肠道微生物的聚集可对其机体各系统产生深远的影响，尤其是肠道免疫系统，即天然免疫(innate immunity)和适应性免疫(adaptive immunity)。鸡肉是人类高效生产蛋白质的主要提供者之一，因此鸡肠道健康问题的解决迫在眉睫。另外，当前抗生素在国内外全面禁用，因此深入了解肠道微生物对家禽免疫的影响十分重要。本文主要阐述了肠道微生物对鸡免疫功能的影响，包括肠道微生物的建立、影响鸡肠道微生物的因素、肠道微生物群的环境因素以及家禽的免疫系统等，并进一步从肠道微生物对各种免疫细胞的调节作用和代谢产物(短链脂肪酸、胆汁酸及色氨酸)等肠道微生物代谢物对机体免疫细胞的调控作用及作用机制等方面阐述肠道微生物对鸡免疫功能的影响。旨在为未来研究疾病易感性、疫苗应答、家禽健康和生产力等方面提供参考。
Abstract:
-

参考文献/References:

［1］Pertea M，Salzberg S L. Between a chicken and a grape：estimating the number of human genes［J］. Genome Biology，2010，11(5)：206.
［2］杨天龙，刘旭川，廖奇，等. 宏基因组技术在鸡肠道微生物中应用的研究进展［J］. 中国畜牧兽医，2017，44(3)：659-666.
［3］Wei S，Morrison M，Yu Z. Bacterial census of poultry intestinal microbiome［J］. Poultry Science，2013，92(3)：671-683.
［4］黄强，文超良，孙从佼，等. 鸡肠道微生物组成及其影响因素［J］. 中国家禽，2021，43(8)：96-105.
［5］Roto S M，Kwon Y M，Ricke S C. Applications of in ovo technique for the optimal development of the gastrointestinal tract and the potential influence on the establishment of its microbiome in poultry［J］. Frontiers in Veterinary Science，2016，3：63.
［6］Clavijo V，Flórez M J V. The gastrointestinal microbiome and its association with the control of pathogens in broiler chicken production：a review［J］. Poultry Science，2018，97(3)：1006-1021.
［7］Kers J G，Velkers F C，Fischer E A J，et al. Host and environmental factors affecting the intestinal microbiota in chickens［J］. Frontiers in Microbiology，2018，9：235.
［8］Ballou A L，Ali R A，Mendoza M A，et al. Development of the chick microbiome：how early exposure influences future microbial diversity［J］. Frontiers in Veterinary Science，2016，3：2.
［9］Oakley B B，Buhr R J，Ritz C W，et al. Successional changes in the chicken cecal microbiome during 42 days of growth are independent of organic acid feed additives［J］. BMC Veterinary Research，2014，10：282.
［10］Han Z F，Willer T，Pielsticker C，et al. Differences in host breed and diet influence colonization by Campylobacter jejuni and induction of local immune responses in chicken［J］. Gut Pathogens，2016，8(1)：56.
［11］Simon K，de Vries Reilingh G，Kemp B，et al. Development of ileal cytokine and immunoglobulin expression levels in response to early feeding in broilers and layers［J］. Poultry Science，2014，93(12)：3017-3027.
［12］Kim J E，Lillehoj H S，Hong Y H，et al. Dietary Capsicum and Curcuma longa oleoresins increase intestinal microbiome and necrotic enteritis in three commercial broiler breeds［J］. Research in Veterinary Science，2015，102：150-158.
［13］Nakphaichit M，Thanomwongwattana S，Phraephaisarn C，et al. The effect of including Lactobacillus reuteri KUB-AC5 during post-hatch feeding on the growth and ileum microbiota of broiler chickens［J］. Poultry Science，2011，90(12)：2753-2765.
［14］Mohd Shaufi M A，Sieo C C，Chong C W，et al. Deciphering chicken gut microbial dynamics based on high-throughput 16S rRNA metagenomics analyses［J］. Gut Pathogens，2015，7：4.
［15］Mignon-Grasteau S，Narcy A，Rideau N，et al. Impact of selection for digestive efficiency on microbiota composition in the chicken［J］. PLoS One，2015，10(8)：e0135488.
［16］Lumpkins B S，Batal A B，Lee M. The effect of gender on the bacterial community in the gastrointestinal tract of broilers［J］. Poultry Science，2008，87(5)：964-967.
［17］Torok V A，Hughes R J，Ophel-Keller K，et al. Influence of different litter materials on cecal microbiota colonization in broiler chickens［J］. Poultry Science，2009，88(12)：2474-2481.
［18］Zhao L L，Wang G，Siegel P，et al. Quantitative genetic background of the host influences gut microbiomes in chickens［J］. Scientific Reports，2013，3：1163.
［19］Xiao Y P，Xiang Y，Zhou W D，et al. Microbial community mapping in intestinal tract of broiler chicken［J］. Poultry Science，2017，96(5)：1387-1393.
［20］安沙，贾友刚，周樱，等. 饲粮中添加酵母多肽对肉鸡生长性能、胴体组成和肠道微生物的影响［J］. 动物营养学报，2022，34(7)：4261-4270.
［21］Broom L J，Kogut M H. The role of the gut microbiome in shaping the immune system of chickens［J］. Veterinary Immunology and Immunopathology，2018，204：44-51.
［22］张利环，贾浩，张若男，等. 复合益生菌对肉鸡肠道微生物区系的影响［J］. 中国畜牧兽医，2022，49(2)：488-500.
［23］Hamal K R，Burgess S C，Pevzner I Y，et al. Maternal antibody transfer from dams to their egg yolks，egg whites，and chicks in meat lines of chickens［J］. Poultry Science，2006，85(8)：1364-1372.
［24］王振鑫，邵丹，宋志刚，等. 热应激对家禽肠道微生物组成与功能的影响及其营养调控研究进展［J］. 中国家禽，2020，42(11)：91-99.
［25］刘石，刘静，陈庄，等. 饮水中添加复合益生菌对岭南黄羽肉鸡生长性能和肠道微生物菌群结构的影响［J］. 中国畜牧兽医，2022，49(1)：98-108.
［26］Fonseca B B，Beletti M E，da Silva M S，et al. Microbiota of the cecum，ileum morphometry，pH of the crop and performance of broiler chickens supplemented with probiotics［J］. Revista Brasileira De Zootecnia，2010，39(8)：1756-1760.
［27］胥彩玉，史兆国，刘国华，等. 微生态制剂对鸡肠道微生物区系影响的研究进展［J］. 中国家禽，2014，36(10)：46-50.
［28］Lamot D M，van de Linde I B，Molenaar R，et al. Effects of moment of hatch and feed access on chicken development［J］. Poultry Science，2014，93(10)：2604-2614.
［29］Johnson C H，Zhao C，Xu Y，et al. Timing the day：what makes bacterial clocks tick？［J］. Nature Reviews Microbiology，2017，15(4)：232-242.
［30］Zarrinpar A，Chaix A，Yooseph S，et al. Diet and feeding pattern affect the diurnal dynamics of the gut microbiome［J］. Cell Metabolism，2014，20(6)：1006-1017.
［31］Schloss P D，Iverson K D，Petrosino J F，et al. The dynamics of a familys gut microbiota reveal variations on a theme［J］. Microbiome，2014，2：25.
［32］Hofshagen M，Kaldhusdal M. Barley inclusion and avoparcin supplementation in broiler diets.1.Effect on small intestinal bacterial flora and performance［J］. Poultry Science，1992，71(6)：959-969.
［33］Ludvigsen J，Svihus B，Rudi K.Rearing room affects the non-dominant chicken cecum microbiota，while diet affects the dominant microbiota［J］. Frontiers in Veterinary Science，2016，3：16.
［34］Bjerrum L，Engberg R M，Leser T D，et al. Microbial community composition of the ileum and cecum of broiler chickens as revealed by molecular and culture-based techniques［J］. Poultry Science，2006，85(7)：1151-1164.
［35］Xu Y H，Yang H X，Zhang L L，et al. High-throughput sequencing technology to reveal the composition and function of cecal microbiota in Dagu chicken［J］. BMC Microbiology，2016，16(1)：259.
［36］Forder R A，Howarth G S，Tivey D R，et al. Bacterial modulation of small intestinal goblet cells and mucin composition during early posthatch development of poultry［J］. Poultry Science，2007，86(11)：2396-2403.
［37］Sohail M U，Hume M E，Byrd J A，et al. Molecular analysis of the caecal and tracheal microbiome of heat-stressed broilers supplemented with prebiotic and probiotic［J］. Avian Pathology，2015，44(2)：67-74.
［38］Oakley B B，Morales C A，Line J，et al. The poultry-associated microbiome：network analysis and farm-to-fork characterizations［J］. PLoS One，2013，8(2)：e57190.
［39］Wang L L，Lilburn M，Yu Z T. Intestinal microbiota of broiler chickens as affected by litter management regimens［J］. Frontiers in Microbiology，2016，7：593.
［40］Cressman M D，Yu Z T，Nelson M C，et al. Interrelations between the microbiotas in the litter and in the intestines of commercial broiler chickens［J］. Applied and Environmental Microbiology，2010，76(19)：6572-6582.
［41］Zhang Q，Eicher S D，Applegate T J. Development of intestinal mucin 2，IgA，and polymeric Ig receptor expressions in broiler chickens and Pekin ducks［J］. Poultry Science，2015，94(2)：172-180.
［42］Chen J X，Tellez G，Richards J D，et al. Identification of potential biomarkers for gut barrier failure in broiler chickens［J］. Frontiers in Veterinary Science，2015，2：14.
［43］Robinson K，Deng Z，Hou Y Q，et al. Regulation of the intestinal barrier function by host defense peptides［J］. Frontiers in Veterinary Science，2015，2(6)：57.
［44］MacPherson A J，Yilmaz B，Limenitakis J P，et al. IgA function in relation to the intestinal microbiota［J］. Annual Review of Immunology，2018，36：359-381.
［45］Ulluwishewa D，Anderson R C，McNabb W C，et al. Regulation of tight junction permeability by intestinal bacteria and dietary components［J］. The Journal of Nutrition，2011，141(5)：769-776.
［46］Abreu M T. Toll-like receptor signalling in the intestinal epithelium：how bacterial recognition shapes intestinal function［J］. Nature Reviews Immunology，2010，10(2)：131-144.
［47］朱丽慧，廖荣荣，杨长锁. 肠道微生物对家禽肠道免疫功能的调节作用及其机制［J］. 动物营养学报，2018，30(3)：820-828.
［48］马晓汶，卢立志，邹晓庭. 家禽肠道微生态与免疫的关系［J］. 中国家禽，2019，41(7)：42-46.
［49］Keestra A M，de Zoete M R，Bouwman L I，et al. Unique features of chicken Toll-like receptors［J］. Developmental and Comparative Immunology，2013，41(3)：316-323.
［50］Wang X，Jia Y Q，Wen L L，et al. Porphyromonas gingivalis promotes colorectal carcinoma by activating the hematopoietic NLRP3 inflammasome［J］. Cancer Research，2021，81(10)：2745-2759.
［51］Lian L，Ciraci C，Chang G B，et al. NLRC5 knockdown in chicken macrophages alters response to LPS and poly (I：C) stimulation［J］. BMC Veterinary Research，2012，8：23.
［52］Shi N，Li N，Duan X W，et al. Interaction between the gut microbiome and mucosal immune system［J］. Military Medical Research，2017，4：14.
［53］Bantug G R，Galluzzi L，Kroemer G，et al. The spectrum of T cell metabolism in health and disease［J］. Nature Reviews Immunology，2018，18(1)：19-34.
［54］Huang R，Liu J Y，Liang W，et al. Response profiles of cytokines and chemokines against avian H9N2 influenza virus within the mouse lung［J］. Medical Microbiology and Immunology，2014，203(2)：109-114.
［55］Kuwabara T，Ishikawa F，Kondo M，et al. The role of IL-17 and related cytokines in inflammatory autoimmune diseases［J］. Mediators of Inflammation，2017，2017：3908061.
［56］徐欣欣，孙其乐，王一汀，等. Th22细胞及其效应因子在自身免疫性皮肤病中的作用研究进展［J］. 中国当代医药，2018，25(25)：43-46.
［57］Bemark M，Boysen P，Lycke N Y.Induction of gut IgA production through T cell-dependent and T cell-independent pathways［J］. Annals of the New York Academy of Sciences，2012，1247(17)：97-116.
［58］Wattrang E. Phosphorothioate oligodeoxyribonucleotides induce in vitro proliferation of chicken B-cells［J］. Veterinary Immunology and Immunopathology，2009，131(3/4)：218-228.
［59］St Paul M，Barjesteh N，Paolucci S，et al. Toll-like receptor ligands induce the expression of interferon-gamma and interleukin-17 in chicken CD+4T cells［J］. BMC Research Notes，2012，5：616.
［60］Reikvam D H，Erofeev A，Sandvik A，et al. Depletion of murine intestinal microbiota：effects on gut mucosa and epithelial gene expression［J］. PLoS One，2011，6(3)：e17996.
［61］杨晓炼，李涵，朱书. 肠道菌群调控宿主天然免疫的机制研究［J］. 中国动物传染病学报，2021，29(4)：16-30.
［62］Schokker D，Veninga G，Vastenhouw S A，et al. Early life microbial colonization of the gut and intestinal development differ between genetically divergent broiler lines［J］. BMC Genomics，2015，16(1)：418.
［63］王涛，胡旭，吴晓丽，等. 肠道共生微生物与免疫［J］. 中国微生态学杂志，2015，27(8)：980-986.
［64］Caballero S，Pamer E G. Microbiota-mediated inflammation and antimicrobial defense in the intestine［J］. Annual Review of Immunology，2015，33：227-256.
［65］Round J L，Lee S M，Li J，et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota［J］. Science，2011，332(6032)：974-977.
［66］石春卫，陈毅秋，胡静涛，等. 肠道微生物群对宿主免疫系统发育和功能的调节［J］. 中国免疫学杂志，2016，32(10)：1536-1540.
［67］Boulton K，Nolan M J，Wu Z G，et al. Phenotypic and genetic variation in the response of chickens to Eimeria tenella induced coccidiosis［J］. Genetics，Selection，Evolution，2018，50(1)：63.
［68］Shanmugasundaram R，Selvaraj R K. Regulatory T cell properties of chicken CD4+CD25+cells［J］. Journal of Immunology，2011，186(4)：1997-2002.
［69］Levy M，Blacher E，Elinav E. Microbiome，metabolites and host immunity［J］. Current Opinion in Microbiology，2017，35：8-15.
［70］Nicolas G R，Chang P V. Deciphering the chemical lexicon of host-gut microbiota interactions［J］. Trends in Pharmacological Sciences，2019，40(6)：430-445.
［71］Arpaia N，Rudensky A Y. Microbial metabolites control gut inflammatory responses［J］. Proceedings of the National Academy of Sciences of the United States of America，2014，111(6)：2058-2059.
［72］Wu W，Sun M，Chen F，et al. Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43［J］. Mucosal Immunology，2017，10(4)：946-956.
［73］Guo C，Qi H，Yu Y J，et al. The G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-κB signaling pathway［J］. Frontiers in Pharmacology，2015，6：287.
［74］Zelante T，Iannitti R G，Cunha C，et al. Tryptophan catabolites from microbiota engage aryl hydrocarbon receptor and balance mucosal reactivity via interleukin-22［J］. Immunity，2013，39(2)：372-385.

相似文献/References:

[1]郭凡溪,钱林东,刘腾飞,等.恩诺沙星联合脂多糖致复合式鸡肝损伤模型的建立[J].江苏农业科学,2013,41(08):212.
　Guo Fanxi,et al.Establishment of composite chicken liver injury model induced by enrofloxacin and LPS[J].Jiangsu Agricultural Sciences,2013,41(11):212.
[2]解慧梅,杜宗沛,刘宗平.苏中地区鸡传染性贫血病感染的血清学调查[J].江苏农业科学,2014,42(11):245.
　Xie Huimei,et al().Serological investigation of chicken infectious anemia infection in middle Jiangsu[J].Jiangsu Agricultural Sciences,2014,42(11):245.
[3]董永军,王宪文,王丽荣.鸡致病性大肠杆菌的分离鉴定及药敏试验[J].江苏农业科学,2013,41(09):192.
　Dong Yunjun,et al.Isolation，identification and drug sensitive test of avian Escherichia coli[J].Jiangsu Agricultural Sciences,2013,41(11):192.
[4]乔海博,谷新利,朱晓庆,等.复方中药多糖不同给药途径对鸡淋巴细胞转化率的影响[J].江苏农业科学,2013,41(10):183.
　Qiao Haibo,et al.Effect of Chinese compound polysaccharide in different administration routes on lymphocyte transformation rate of chicks[J].Jiangsu Agricultural Sciences,2013,41(11):183.
[5]时凯,杨智青,金崇富,等.沿海林间生态养殖不同品种鸡的效益对比分析[J].江苏农业科学,2013,41(12):224.
　Shi Kai,et al.Comparative analysis of economic benefits of different varieties of chickens under ecological farming in coastal forests[J].Jiangsu Agricultural Sciences,2013,41(11):224.
[6]徐晟,贾胜军,熊喜龙.不同甲苯胺蓝染液对显示鸡肠管肥大细胞的影响[J].江苏农业科学,2013,41(12):225.
　Xu Sheng,et al.Effects of different toluidine blue stains on presenting intestinal mast cells in chickens[J].Jiangsu Agricultural Sciences,2013,41(11):225.
[7]陈则东,沈晓鹏,穆洪云.鸡IGF2基因外显子1的多态性及其与生产性能的相关性[J].江苏农业科学,2016,44(06):331.
　Chen Zedong,et al.Polymorphism of chicken IGF2 gene exon 1 and its correlation with production performance[J].Jiangsu Agricultural Sciences,2016,44(11):331.
[8]张金龙,李新华,贾胜军.鸡体腔被打开后气囊活动情况[J].江苏农业科学,2014,42(03):153.
　Zhang Jinlong,et al.Activity of air vesicle in celom-opened chicken[J].Jiangsu Agricultural Sciences,2014,42(11):153.
[9]孙勇,曹小迎,蒋继宏,等.华北大黑鳃金龟幼虫肠道菌的分离及对农药的降解[J].江苏农业科学,2016,44(02):151.
　Sun Yong,et al.Isolation and pesticides degradation of intestinal microflora from Holotrichia oblita larvae[J].Jiangsu Agricultural Sciences,2016,44(11):151.
[10]李贵萧,朱宗涛,康燕青,等.鸡大肠杆菌的血清抗性与致病性检验[J].江苏农业科学,2015,43(11):301.
　Li Guixiao,et al.Serum resistance and pathogenicity of avian Escherichia coli[J].Jiangsu Agricultural Sciences,2015,43(11):301.

备注/Memo

备注/Memo:
收稿日期：2022-09-01
基金项目：广东省家禽产业技术体系创新团队建设项目(编号：2021KJ128)；广东省科技创新战略专项基金(编号：DZX20192520309)；广东省教育厅重点研究领域专项基金(编号：2019KZDZX2006)。
作者简介：岑明珠(1992—)，女，广东阳江人，硕士研究生，研究方向为动物营养与饲料。E-mail：752565191@qq.com。
通信作者：张辉华，博士，教授，硕士生导师，研究方向为动物营养与饲料。E-mail：hhzhang2@163.com。
更新日期/Last Update: 2023-06-05