4种花色苷在Caco-2细胞单层模型的转运吸收规律-《江苏农业科学》

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Title:: Study on transport and absorption of four kinds of anthocyanins in Caco-2 cell monolayer model

作者:: 苏丽¹; 党庆玲²; 高瑞昌²; 1.宁夏贺兰山东麓葡萄产业园区管理委员会，宁夏银川 753000； 2.江苏大学食品与生物工程学院，江苏镇江 212013

Author(s):: Su Li; et al

关键词:: 花色苷; 人结肠腺癌细胞单层模型; 转运吸收

Keywords:: -

分类号:: TS201.4

DOI:: -

文献标志码:: A

摘要:: 以Caco-2单层细胞为体外吸收评价模型，以矢车菊素-3-葡萄糖苷(Cy-3-G)、飞燕草素-3-葡萄糖苷(Dp-3-G)、锦葵素-3-葡萄糖苷(Mv-3-G)、天竺葵素-3-葡萄糖苷(Pg-3-G)为对象，研究其跨膜吸收规律。结果表明，在相同浓度下，4种花色苷在Caco-2细胞单层模型中的吸收表现为 Mv-3-G最高，其次依次为 Pg-3-G、Cy-3-G、Dp-3-G，它们在Caco-2细胞的吸收过程中均存在外排现象，但是相互间的外排率无显著性差异。花色苷在Caco-2单层细胞吸收过程中的双向转运对时间有一定依赖性，正向的转运吸收作用比反向的外排作用大，且存在显著方向性，参与吸收的途径有主动运输和被动运输。花色苷苷元结构上的基团差异可能是导致其跨膜吸收差异的结构基础，转运方式的不同是其吸收差异的另一个原因。

Abstract:: -

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