HIV-1整合酶四聚体的模建及结构基础研究-《江苏农业科学》

参考文献/References:

［1］Weiss R A. How does HIV cause AIDS?［J］. Science，1993，260(5112)：1273-1279.
［2］World Health Organization. Global summary of the AIDS epidemic 2014［R］. Geneva，Switzerland：WHO，2015.
［3］Pommier Y，Johnson A A，Marchand C. Integrase inhibitors to treat HIV/AIDS［J］. Nat Rev Drug Discov，2005，4(3)：236-248.
［4］Neamati N. HIV-1 integrase inhibitor design：overview and historical perspectives［M］//HIV-1 integrase：mechanism and inhibitor design. John Wiley & Sons Inc，2011.
［5］Dayam R，Al-Mawsawi L Q，Neamati N. HIV-1 integrase inhibitors：an emerging clinical reality［J］. Drugs in R & D，2007，8(3)：155-168.
［6］Heuer T S，Brown P O. Mapping features of HIV-1 integrase near selected sites on viral and target DNA molecules in an active enzyme-DNA complex by photo-cross-linking［J］. Biochemistry，1997，36(35)：10655-10665.
［7］Bushman F D，Engelman A，Palmer I，et al. Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding［J］. Proceedings of the National Academy of Sciences，1993，90(8)：3428-3432.
［8］Ellison V，Gerton J，Vincent K A，et al. An essential interaction between distinct domains of HIV-1 integrase mediates assembly of the active multimer［J］. Journal of Biological Chemistry，1995，270(7)：3320-3326.
［9］Rice P A，Baker T A. Comparative architecture of transposase and integrase complexes［J］. Nature Structural & Molecular Biology，2001，8(4)：302-307.
［10］Engelman A，Hickman A B，Craigie R. The core and carboxyl-terminal domains of the integrase protein of human immunodeficiency virus type 1 each contribute to nonspecific DNA binding［J］. Journal of Virology，1994，68(9)：5911-5917.
［11］Lutzke R A P，Vink C，Plasterk R H A. Characterization of the minimal DNA-binding domain of the HIV integrase protein［J］. Nucleic Acids Research，1994，22(20)：4125-4131.
［12］Vink C，Oude G A M，Plasterk R H. Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein［J］. Nucleic Acids Research，1993，21(6)：1419-1425.
［13］Zhu K，Dobard C，Chow S A. Requirement for integrase during reverse transcription of human immunodeficiency virus type 1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase［J］. Journal of Virology，2004，78(10)：5045-5055.
［14］Hehl E A，Joshi P，Kalpana G V，et al. Interaction between human immunodeficiency virus type 1 reverse transcriptase and integrase proteins［J］. Journal of Virology，2004，78(10)：5056-5067.
［15］Cherepanov P，Maertens G，Proost P，et al. HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells［J］. Journal of Biological Chemistry，2003，278(1)：372-381.
［16］Yang W，Steitz T A. Recombining the structures of HIV integrase，RuvC and RNase H［J］. Structure，1995，3(2)：131-134.
［17］Maignan S，Guilloteau J P，Zhou-Liu Q，et al. Crystal structures of the catalytic domain of HIV-1 integrase free and complexed with its metal cofactor：high level of similarity of the active site with other viral integrases［J］. Journal of Molecular Biology，1998，282(2)：359-368.
［18］Cai M，Zheng R，Caffrey M，et al. Solution structure of the N-terminal zinc binding domain of HIV-1 integrase［J］. Nature Structural Biology，1997，4(7)：567-577.
［19］Chen J C，Krucinski J，Miercke L J W，et al. Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains：a model for viral DNA binding［J］. Proc Natl Acad Sci，2000，97(15)：8233-8238.
［20］Wang J Y，Ling H，Yang W，et al. Structure of a two-domain fragment of HIV-1 integrase：implications for domain organization in the intact protein［J］. The EMBO Journal，2001，20(24)：7333-7343.
［21］Jorgensen W L，Chandrasekhar J，Madura J D，et al. Comparison of simple potential functions for simulating liquid water［J］. J Chem Phys，1983，79 (2)：926-935.
［22］张青青，姚其正，张生平，等. 靛玉红类CDK1抑制剂的同源模建、分子对接及3D-QSAR研究［J］. 物理化学学报，2014，30(2)：371-381.
［23］Erman B. The Gaussian network model：precise predictions of residue fluctuations and application to binding problems［J］. Biophysical Journal，2006，91(10)：3589-3599.
［24］Jernigan R L，Demirel M C，Bahar I. Relating structure to function through the dominant slow modes of motion of DNA topoisomerase Ⅱ［J］. International Journal of Quantum Chemistry，2015，75(3)：301-312.
［25］Reznikoff W S. Tn5 as a model for understanding DNA transposition［J］. Molecular Microbiology，2003，47(5)：1199-1206.
［26］Bahar I，Lezon T R，Yang L W，et al. Global dynamics of proteins：bridging between structure and function［J］. Annual Review of Biophysics，2010，39(1)：23.
［27］Davies D R，Goryshin I Y，Reznikoff W S，et al. Three-dimensional structure of the Tn5 synaptic complex transposition intermediate［J］. Science，2000，289(5476)：77-85.
［28］Steiniger-White M，Bhasin A，Lovell S，et al. Evidence for “unseen” transposase-DNA contacts［J］. Journal of Molecular Biology，2002，322(5)：971-982.
［29］Lovell S，Goryshin I Y，Reznikoff W R，et al. Two-metal active site binding of a Tn5 transposase synaptic complex［J］. Nature Structural & Molecular Biology，2002，9(4)：278-281.
［30］Klenchin V A，Czyz A，Goryshin I Y，et al. Phosphate coordination and movement of DNA in the Tn5 synaptic complex：role of the (R) YREK motif［J］. Nucleic Acids Research，2008，36(18)：5855-5862.
［31］Steiniger-White M，Rayment I，Reznikoff W S. Structure/function insights into Tn5 transposition［J］. Current Opinion in Structural Biology，2004，14(1)：50-57.
［32］Long Y Q，Jiang X H，Dayam R，et al. Rational design and synthesis of novel dimeric diketoacid containing inhibitors of HIV-1 integrase：Implication for binding to two metal ions on the active site of integrase［J］. J Med Chem，2004，47(10)：2561-2573
［33］Dayam R，Neamati N. Active site binding modes of the betadiketoacids：A multi-active site approach in HIV-1 integrase inhibitor design［J］. Bioorg & Med Chem，2004，12(24)：6371-6381.

《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

文章信息/Info

参考文献/References:

相似文献/References:

备注/Memo

常用功能

导航/Navigate

工具/Tools

统计/Statistics