|本期目录/Table of Contents|

[1]程广超,杨萍,赫晨,等.社会隔离对雌性小鼠动情周期及中枢ERα和TH免疫活性表达的影响[J].江苏农业科学,2019,47(14):197-201.
　Cheng Guangchao,et al.Impacts of social isolation on estrous cycle and immunoreactivity of ERα and TH in female mice[J].Jiangsu Agricultural Sciences,2019,47(14):197-201.
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社会隔离对雌性小鼠动情周期及中枢ERα
和TH免疫活性表达的影响(PDF)
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《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第47卷
期数:
2019年第14期
页码:
197-201
栏目:
畜牧兽医与水产蚕桑
出版日期:
2019-08-10

文章信息/Info

Title:
Impacts of social isolation on estrous cycle and immunoreactivity of ERα and TH in female mice
作者:
程广超1; 2;  杨萍1;  赫晨1;  杨斌1;  王建礼1; 2
1.北方民族大学生物科学与工程学院，宁夏银川 750021； 2.国家民委生态建模与应用重点实验室，宁夏银川 750021
Author(s):
Cheng Guangchao; et al
关键词:
隔离; 雌性小鼠; 动情周期; 雌激素; 多巴胺; 免疫活性表达
Keywords:
-
分类号:
Q492
DOI:
-
文献标志码:
A
摘要:
雌激素受体(ERα)和多巴胺(DA)可参与雌性动物动情周期调节，故本研究通过酪氨酸羟化酶(TH)标记DA神经元，探讨了社会隔离对雌性动情周期及ERα和DA的影响。成年雌性ICR小鼠社会隔离10 d后，检测其动情周期变化及动情期和动情间期中枢ERα-IR和TH-IR神经元表达。结果发现，社会隔离延长了雌鼠的动情前期和动情期(P<0.05)，但对动情后期和动情间期没有影响；社会隔离和动情周期均会显著影响终纹床核(BNST)、内侧视前区(MPOA)和下丘脑弓状核(AR)的ERα-IR神经元表达(P<0.05)，并对AR的ERα-IR表达和中脑腹侧被盖区(VTA)的TH-IR神经元表达有交互影响(P<0.05)，表现为社会隔离减少动情期AR的ERα-IR表达(P<0.05)，增加动情期和动情间期TH-IR表达(P<0.05)，且对动情期的影响更明显。提示社会隔离会干扰雌鼠的动情周期，ERα和DA在特定脑区的变化对此具有重要调制作用。
Abstract:
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相似文献/References:

备注/Memo

备注/Memo:
收稿日期：2018-03-30
基金项目：国家自然科学基金(编号：31460565)；宁夏优秀人才支持计划；宁夏回族自治区大学生创新计划(编号：QJCX-2017-033)。
作者简介：程广超(1990—)，男，内蒙古赤峰人，硕士，主要从事行为生理学研究。E-mail：761408199@qq.com。
通信作者：王建礼，博士，教授，主要从事行为生理学研究。E-mail：wang_jianli@163.com。
更新日期/Last Update: 2019-07-20