[1]王淼,周杰,陈鸽,等.纳米生物农药的设计及控缓释研究进展[J].江苏农业科学,2023,51(17):9-18.
　Wang Miao,et al.Research progress on design and controlled release of nano bio-pesticides[JY。]Wang Miao，et al(9)[J].Jiangsu Agricultural Sciences,2023,51(17):9-18.
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纳米生物农药的设计及控缓释研究进展()

《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第51卷
期数:
2023年第17期
页码:
9-18
栏目:
专论与综述
出版日期:
2023-09-05

文章信息/Info

Title:
Research progress on design and controlled release of nano bio-pesticides[JY。]Wang Miao，et al(9)
作者:
王淼1; 2; 周杰1; 陈鸽1; 李凌云1; 李森2; 郭兆将1; 徐东辉1; 2; 黄晓冬1; 刘广洋1
1.中国农业科学院蔬菜花卉研究所，北京 100081； 2.山西农业大学园艺学院，山西晋中 030801
Author(s):
Wang Miao; et al
关键词:
生物农药; 纳米材料; 纳米载体; 控缓释技术; 纳米农药
Keywords:
-
分类号:
TQ450.6+8
DOI:
-
文献标志码:
A
摘要:
生物农药是一种环境无害、生物友好、病虫害防治特异性高的绿色农药。与化学农药相比，生物农药以较低毒害作用、良好的环境相容性、对人畜较为安全、开发成本低等特性被推广使用。然而，生物农药见效缓慢、产品质量稳定性差、施用有效期短、易受环境因素影响等缺点严重制约了其发展。农药纳米载体是指将农药有效成分通过静电相互作用、范德华力、π-π键的相互作用等以吸附、偶联、包覆、镶嵌等方式负载于纳米材料中的缓释剂型。基于新型纳米材料的控缓释技术能够有效克服上述生物农药的缺点，达到增强药效、提高农药利用率、靶向传输和精准缓释控释的防治效果。目前，化学农药控缓释研究较多，但针对生物农药的相关研究相对较少。本文简要介绍了生物农药的发展现状及存在的问题，重点阐述了纳米材料作为智能控释载体控缓释生物农药的应用进展，并展望了其在可持续农业中的发展前景，为今后生物农药的高效利用和推广提供了理论依据。
Abstract:
-

参考文献/References:

［1］中国农药信息网，中华人民共和国农业农村部农药检定所. 农药登记数据［EB/OL］. ［2022-06-03］. http：//www.chinapesticide.org.cn/hysj/index.jhtml.
［2］王晓庭. 生物农药发展现状及趋势分析［J］. 山西林业科技，2021，50(4)：61-62.
［3］刘月悦. 纳米生物农药-6%烟碱微胶囊包载缓释剂的制备与药效评价［D］. 雅安：四川农业大学，2014：13-14.
［4］刘潇. 生物化学农药发展现状及趋势分析［J］. 化学工业，2021，39(1)：53-58.
［5］朱英慧. 生物农药应用中存在的问题及对策［J］. 南方农业，2018，12(15)：62-63.
［6］李金金. 探究生物农药的发展现状与趋势［J］. 农家参谋，2020(22)：202.
［7］Zhao X，Cui H X，Wang Y，et al. Development strategies and prospects of nano-based smart pesticide formulation［J］. Journal of Agricultural and Food Chemistry，2018，66(26)：6504-6512.
［8］潘华，李文婧，吴立涛，等. 新型纳米农药制剂载体材料的研究进展［J］. 材料导报，2020，34(增刊2)：1099-1103.
［9］Pascoli M，Lopes-Oliveira P J，Fraceto L F，et al. State of the art of polymeric nanoparticles as carrier systems with agricultural applications：a minireview［J］. Energy Ecology and Environment，2018，3(7)：137-148.
［10］Huang B N，Chen F F，Shen Y E，et al. Advances in targeted pesticides with environmentally responsive controlled release by nanotechnology［J］. Nanomaterials，2018，8(2)：102.
［11］Kah M，Hofmann T. Nanopesticide research：current trends and future priorities［J］. Environment International，2014，63：224-235.
［12］Kumar S，Nehra M，Dilbaghi N，et al. Nano-based smart pesticide formulations：emerging opportunities for agriculture［J］. Journal of Controlled Release，2019，294：131-153.
［13］Abasian P，Ghanavati S，Rahebi S，et al. Polymeric nanocarriers in targeted drug delivery systems：a review［J］. Polymers for Advanced Technologies，2020，31(12)：2939-2954.
［14］Chen H，Yuan L，Song W，et al. Biocompatible polymer materials：role of protein-surface interactions［J］. Progress in Polymer Science，2008，33(11)：1059-1087.
［15］Feng B H，Ashraf M A，Peng L F.Characterization of particle shape，zeta potential，loading efficiency and outdoor stability for chitosan-ricinoleic acid loaded with rotenone［J］. Open Life Sciences，2016，11(1)：380-386.
［16］Kim H，Lah M S. Templated and template-free fabrication strategies for zero-dimensional hollow MOF superstructures［J］. Dalton Transactions，2017，46(19)：6146-6158.
［17］闫硕，蒋沁宏，沈杰. 纳米农药及载体材料的增效机理研究现状［J］. 植物保护学报，2022，49(1)：366-381.
［18］Peng R F，Yang D J，Qiu X Q，et al. Preparation of self-dispersed lignin-based drug-loaded material and its application in avermectin nano-formulation［J］. International Journal of Biological Macromolecules，2020，151：421-427.
［19］Yang Y，Cheng J G，Garamus V M，et al. Preparation of an environmentally friendly formulation of the insecticide nicotine hydrochloride through encapsulation in chitosan/tripolyphosphate nanoparticles［J］. Journal of Agricultural and Food Chemistry，2018，66(5)：1067-1074.
［20］Zhou M S，Xiong Z C，Yang D J，et al. Preparation of slow release nanopesticide microspheres from benzoyl lignin［J］. Holzforschung，2018，72(7)：599-607.
［21］Sun C J，Zeng Z H，Cui H X，et al. Polymer-based nanoinsecticides：current developments，environmental risks and future challenges. A review［J］. Biotechnol Agron Soc Environ，2020，24(2)：59-69.
［22］Lu B T，Lv X K，Le Y. Chitosan-modified PLGA nanoparticles for control-released drug delivery［J］. Polymers，2019，11(2)：304-318.
［23］Sun C J，Yu M L，Zeng Z H，et al. Biocidal activity of polylactic acid-based nano-formulated abamectin on Acyrthosiphon pisum (Hemiptera：Aphididae) and the aphid predator Adalia bipunctata (Coleoptera：Coccinellidae)［J］. PLoS One，2020，15(2)：e0228817.
［24］Sun D Q，Hussain H I，Yi Z F，et al. Delivery of abscisic acid to plants using glutathione responsive mesoporous silica nanoparticles［J］. Journal of Nanoscience and Nanotechnology，2018，18(3)：1615-1625.
［25］Wang Q，OHare D.Recent advances in the synthesis and application of layered double hydroxide (LDH) nanosheets［J］. Chemical Reviews，2012，112(7)：4124-4155.
［26］Nadiminti P P，Sharma H，Kada S R，et al. Use of Mg-Al nanoclay as an efficient vehicle for the delivery of the herbicide 2，4-dichlorophenoxyacetic acid［J］. ACS Sustainable Chemistry & Engineering，2019，7(12)：10962-10970.
［27］Sun C J，Wang Y，Zhao X A，et al. Properties of avermectin delivery system using surfactant-modified mesoporous activated carbon as a carrier［J］. Journal of Nanomaterials，2018(2)：1-6.
［28］Shan Y P，Xu C L，Zhang H J，et al. Polydopamine-modified metal-organic frameworks，NH2-Fe-MIL-101，as pH-sensitive nanocarriers for controlled pesticide release［J］. Nanomaterials，2020，10(10)：2000.
［29］Rao C Y，Liao D H，Pan Y，et al. Novel formulations of metal-organic frameworks for controlled drug delivery［J］. Expert Opinion on Drug Delivery，2022，19(10)：1183-1202.
［30］Ma Y J，Nolte R J M，Cornelissen J J L M.Virus-based nanocarriers for drug delivery［J］. Advanced Drug Delivery Reviews，2012，64(9)：811-825.
［31］Masarapu H，Patel B K，Chariou P L，et al. Physalis mottle virus-like particles as nanocarriers for imaging reagents and drugs［J］. Biomacromolecules，2017，18(12)：4141-4153.
［32］Yan Y F，Hou H W，Ren T R，et al. Utilization of environmental waste cyanobacteria as a pesticide carrier：studies on controlled release and photostability of avermectin［J］. Colloids and Surfaces B：Biointerfaces，2013，102：341-347.
［33］孙长娇，王琰，赵翔，等. 纳米农药剂型与其减施增效机理研究进展［J］. 农药学学报，2020，22(2)：205-213.
［34］de Oliveira J L，Campos E V R，Bakshi M，et al. Application of nanotechnology for the encapsulation of botanical insecticides for sustainable agriculture：prospects and promises［J］. Biotechnology Advances，2014，32(8)：1550-1561.
［35］Stuart M A C，Huck W T S，Genzer J，et al. Emerging applications of stimuli-responsive polymer materials［J］. Nature Materials，2010，9(2)：101-113.
［36］Kamari A，Aljafree N F A，Yusoff S N M. Oleoyl-carboxymethyl chitosan as a new carrier agent for the rotenone pesticide［J］. Environmental Chemistry Letters，2016，14(3)：417-422.
［37］Aljafree N F A，Kamari A. Synthesis，characterisation and potential application of deoxycholic acid carboxymethyl chitosan as a carrier agent for rotenone［J］. Journal of Polymer Research，2018，25(6)：133-145.
［38］Zhang Y，Luo M M，Xu W P，et al. Avermectin confers its cytotoxic effects by inducing DNA damage and mitochondria-associated apoptosis［J］. Journal of Agricultural and Food Chemistry，2016，64(36)：6895-6902.
［39］Cui B，Wang C X，Zhao X A，et al. Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques［J］. PLoS One，2018，13(1)：e0191742.
［40］He S，Zhang W B，Li D G，et al. Preparation and characterization of double-shelled avermectin microcapsules based on copolymer matrix of silica-glutaraldehyde-chitosan［J］. Journal of Materials Chemistry B，2013，1(9)：1270-1278.
［41］Chen H Y，Zhi H，Liang J E，et al. Development of leaf-adhesive pesticide nanocapsules with pH-responsive release to enhance retention time on crop leaves and improve utilization efficiency［J］. Journal of Materials Chemistry B，2021，9(3)：783-792.
［42］Zhou M，Wang D，Yang D，et al. Avermectin loaded nanosphere prepared from acylated alkali lignin showed anti-photolysis property and controlled release performance［J］. Industrial Crops and Products，2019，137：453-459.
［43］Kamari A，Aljafree N F A，Yusoff S N M. N，N-dimethylhexadecyl carboxymethyl chitosan as a potential carrier agent for rotenone［J］. International Journal of Biological Macromolecules，2016，88：263-272.
［44］Yusoff S N M，Kamari A.N-deoxycholic acid-O-glycol chitosan as a potential carrier agent for botanical pesticide rotenone［J］. Journal of Applied Polymer Science，2018，135(47)：46855.
［45］Lao S B，Zhang Z X，Xu H H，et al. Novel amphiphilic chitosan derivatives：synthesis，characterization and micellar solubilization of rotenone［J］. Carbohydrate Polymers，2010，82(4)：1136-1142.
［46］Gupta S C，Prasad S，Tyagi A K，et al. Neem (Azadirachta indica)：an indian traditional panacea with modern molecular basis［J］. Phytomedicine，2017，34：14-20.
［47］Shah F M，Razaq M，Ali A，et al. Comparative role of neem seed extract，moringa leaf extract and imidacloprid in the management of wheat aphids in relation to yield losses in Pakistan［J］. PLoS One，2017，12(9)：1-24.
［48］Kumar J，Shakil N A，Singh M K，et al. Development of controlled release formulations of azadirachtin-a employing poly(ethylene glycol) based amphiphilic copolymers［J］. Journal of Environmental Science and Health(Part B)，2010，45(4)：310-314.
［49］Plohl O，Gyergyek S，Zemljicˇ L F. Mesoporous silica nanoparticles modified with N-rich polymer as a potentially environmentally-friendly delivery system for pesticides［J］. Microporous and Mesoporous Materials，2021，310：110663.
［50］Wang C Y，Lou X Y，Cai Z，et al. Supramolecular nanoplatform based on mesoporous silica nanocarriers and pillararene nanogates for fungus control［J］. ACS Applied Materials & Interfaces，2021，13(27)：32295-32306.
［51］Liang Y，Gao Y H，Wang W C，et al. Fabrication of smart stimuli-responsive mesoporous organosilica nano-vehicles for targeted pesticide delivery［J］. J Hazard Mater，2020，389：122075-122086.
［52］张志龙. 中空介孔二氧化硅的制备及其性能研究［D］. 南京：东南大学，2016：9-10.
［53］Kaziem A E，Gao Y H，Zhang Y，et al. α-Amylase triggered carriers based on cyclodextrin anchored hollow mesoporous silica for enhancing insecticidal activity of avermectin against Plutella xylostella［J］. Journal of Hazardous Materials，2018，359：213-221.
［54］Gao Y H，Zhang Y H，He S，et al. Fabrication of a hollow mesoporous silica hybrid to improve the targeting of a pesticide［J］. Chemical Engineering Journal，2019，364：361-369.
［55］Gupta V K，Carrott P J M，Singh R，et al. Cellulose：a review as natural，modified and activated carbon adsorbent［J］. Bioresource Technology，2016，216：1066-1076.
［56］孙长娇，崔海信，刘琪，等. 介孔活性炭阿维菌素载药系统的性能研究［J］. 农药学学报，2010，12(2)：214-220.
［57］Baldassarre F，de Stradis A，Altamura G，et al. Application of calcium carbonate nanocarriers for controlled release of phytodrugs against Xylella fastidiosa pathogen［J］. Pure and Applied Chemistry，2020，92(3)：429-444.
［58］肖豆鑫. 基于纤维素碳酸钙载体的功能化农药制剂构建及性能研究［D］. 杭州：浙江大学，2021：7-8.
［59］Qian H，Hu B，Wang Z，et al. Effects of validamycin on some enzymatic activities in soil［J］. Environ Monit Assess，2007，125(1/2/3)：1-8.
［60］Qian K，Shi T Y，Tang T，et al. Preparation and characterization of nano-sized calcium carbonate as controlled release pesticide carrier for validamycin against Rhizoctonia solani［J］. Microchimica Acta，2011，173(1)：51-57.
［61］Rao W H，Zhan Y T，Chen S L，et al. Flowerlike Mg(OH)2 cross-nanosheets for controlling Cry1Ac protein loss：evaluation of insecticidal activity and biosecurity［J］. Journal of Agricultural and Food Chemistry，2018，66(14)：3651-3657.
［62］Jenne M，Kambham M，Tollamadugu N V K V P，et al. The use of slow releasing nanoparticle encapsulated azadirachtin formulations for the management of Caryedon serratus O.(groundnut bruchid)［J］. IET Nanobiotechnology，2018，12(7)：963-967.
［63］Deng L X，He J J，Li B R，et al. Study of a new 3D MOF and its adsorption，slow release and biological activity in water-soluble and oil-soluble pesticides［J］. Polyhedron，2020，190：114752.
［64］Liang W L，Cheng J L，Zhang J D，et al. pH-responsive on-demand alkaloids release from core-shell ZnO@ZIF-8 nanosphere for synergistic control of bacterial wilt disease［J］. ACS Nano，2022，16(2)：2762-2773.
［65］Cao J，Guenther R H，Sit T L，et al. Development of abamectin loaded plant virus nanoparticles for efficacious plant parasitic nematode control［J］. ACS Applied Materials & Interfaces，2015，7(18)：9546-9553.
［66］de Oliveira J L，Campos E V R，Germano-Costa T，et al. Association of zein nanoparticles with botanical compounds for effective pest control systems［J］. Pest Management Science，2019，75(7)：1855-1865.
［67］Monteiro R A，Camara M C，de Oliveira J L，et al. Zein based-nanoparticles loaded botanical pesticides in pest control：an enzyme stimuli-responsive approach aiming sustainable agriculture［J］. Journal of Hazardous Materials，2021，417：126004.
［68］Wu J H，Du C L，Zhang J M，et al. Synthesis of Metarhizium anisopliae-chitosan nanoparticles and their pathogenicity against Plutella xylostella (Linnaeus)［J］. Microorganisms，2021，10(1)：1-15.
［69］Gabriel Paulraj M，Ignacimuthu S，Gandhi M R，et al. Comparative studies of tripolyphosphate and glutaraldehyde cross-linked chitosan-botanical pesticide nanoparticles and their agricultural applications［J］. International Journal of Biological Macromolecules，2017，104：1813-1819.
［70］Fu Z N，Chen K，Li L，et al. Spherical and spindle-like abamectin-loaded nanoparticles by flash nanoprecipitation for southern root-knot nematode control：preparation and characterization［J］. Nanomaterials，2018，8(6)：449.
［71］Papanikolaou N E，Kalaitzaki A，Karamaouna F，et al. Nano-formulation enhances insecticidal activity of natural pyrethrins against Aphis gossypii (Hemiptera：Aphididae) and retains their harmless effect to non-target predators［J］. Environmental Science and Pollution Research，2018，25(11)：10243-10249.
［72］Wang A Q，Wang Y，Sun C J，et al. Fabrication，characterization，and biological activity of avermectin nano-delivery systems with different particle sizes［J］. Nanoscale Research Letters，2018，13(1)：2.
［73］Liu X X，Zheng Y，Zhang S B，et al. Perylenediimide-cored cationic nanocarriers deliver virus DNA to kill insect pests［J］. Polymer Chemistry，2016，7(22)：3740-3746.
［74］Zhang Y，Liu B Y，Huang K X，et al. Eco-friendly castor oil-based delivery system with sustained pesticide release and enhanced retention［J］. ACS Applied Materials & Interfaces，2020，12(33)：37607-37618.
［75］Yan S，Hu Q A，Li J H，et al. A star polycation acts as a drug nanocarrier to improve the toxicity and persistence of botanical pesticides［J］. ACS Sustainable Chemistry & Engineering，2019，7(20)：17406-17413.
［76］Shen Z C，Wen H J，Zhou H J，et al. Coordination bonding-based polydopamine-modified mesoporous silica for sustained avermectin release［J］. Materials Science and Engineering(C)，2019，105：110073.
［77］Sattary M，Amini J，Hallaj R. Antifungal activity of the lemongrass and clove oil encapsulated in mesoporous silica nanoparticles against wheats take-all disease［J］. Pesticide Biochemistry and Physiology，2020，170：104696.
［78］Feng J G，Chen W，Shen Y M，et al. Fabrication of abamectin-loaded mesoporous silica nanoparticles by emulsion-solvent evaporation to improve photolysis stability and extend insecticidal activity［J］. Nanotechnology，2020，31(34)：345705.
［79］Fu Z N，Li L，Wang Y M，et al. Direct preparation of drug-loaded mesoporous silica nanoparticles by sequential flash nanoprecipitation［J］. Chemical Engineering Journal，2020，382：122905.
［80］Mattos B D，Rojas O J，Magalhes W L E. Biogenic silica nanoparticles loaded with neem bark extract as green，slow-release biocide［J］. Journal of Cleaner Production，2017，142：4206-4213.

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　Hu Yonghong,et al.Research progress of polyoxin[J].Jiangsu Agricultural Sciences,2013,41(17):1.
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备注/Memo

备注/Memo:
收稿日期：2022-11-16
基金项目：国家自然科学基金(编号：31872947)；中国农业科学院重大科研任务(编号：CAAS-ZDRW202011、CAAS-XTCX2019025)；国家现代农业技术产业体系建设专项(编号：CARS-23-E03)。
作者简介：王淼(1999—)，女，河北保定人，硕士研究生，从事纳米农药的制备及其应用研究。E-mail：wmmwm001@163.com。
通信作者：徐东辉，博士，研究员，从事蔬菜产品营养品质与质量安全控制研究，E-mail：xudonghui@caas.cn；刘广洋，博士，副研究员，从事新型纳米材料创制及蔬菜质量安全应用研究，E-mail：liuguangyang@caas.cn。
更新日期/Last Update: 2023-09-05