桑树潜在致敏原鉴定与生物信息学分析-《江苏农业科学》

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Title:: Identification and bioinformatic analysis of potential allergens in Morus notabilis

作者:: 刘潮; 韩利红; 宋培兵; 张亚萍; 唐利洲; 曲靖师范学院云南高原生物资源保护与利用研究中心/云南省高校云贵高原动植物多样性及生态适应性进化重点实验室，云南曲靖 655011

Author(s):: Liu Chao; et al

关键词:: 致敏原; 桑树; 过敏反应; 生物信息学

Keywords:: -

分类号:: S888.2

DOI:: -

文献标志码:: A

摘要:: 致敏原是能引发Ⅰ型过敏反应的抗原性物质，桑树的花粉和果实均能引起人的过敏反应。为了解桑树的潜在致敏原信息，以报道的致敏原为探针，搜索桑树蛋白数据库，获得桑树潜在致敏原信息，并对其家族分布、结构和功能进行分析。结果显示，共获得143条桑树的潜在致敏原蛋白，它们分属于71个不同的基因本体(gene ontology，简称GO)注释子条目和49个pfam家族，且其结构和功能各不相同。其中多个成员属于常见的致敏家族，如Bet v 1家族、Profilin家族、Thaumatin家族、RlpA-like_DPBB家族，与已鉴定的致敏原具有较高的序列一致性和相似的三级结构。研究结果有助于过敏症的临床诊断和交叉反应的预警。

Abstract:: -

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