[1]许地元,叶萍,李海丽,等.苞叶雪莲总黄酮提取工艺优化及其粗提物抗肿瘤活性[J].江苏农业科学,2021,49(4):130-134.
Xu Diyuan,et al.Optimization of extraction technology of total flavonoids from Saussurea obvallata and anti-tumor activity of its crude extract[J].Jiangsu Agricultural Sciences,2021,49(4):130-134.
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苞叶雪莲总黄酮提取工艺优化及其粗提物抗肿瘤活性(PDF)
Xu Diyuan,et al.Optimization of extraction technology of total flavonoids from Saussurea obvallata and anti-tumor activity of its crude extract[J].Jiangsu Agricultural Sciences,2021,49(4):130-134.
《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]
- 卷:
- 第49卷
- 期数:
- 2021年第4期
- 页码:
- 130-134
- 栏目:
- 贮藏加工与检测分析
- 出版日期:
- 2021-02-20
文章信息/Info
- Title:
- Optimization of extraction technology of total flavonoids from Saussurea obvallata and anti-tumor activity of its crude extract
- 作者:
- 许地元1; 2; 叶萍1; 3; 李海丽1; 2; 3; 林鹏程1; 2; 3
-
1.青海民族大学药学院，青海西宁 810007；2.青藏高原植物化学重点实验室，青海西宁 810007；
3.青海省药物分析重点实验室，青海西宁 810007
- Keywords:
- -
- 分类号:
- R284
- DOI:
- -
- 文献标志码:
- A
- 摘要:
- 为了明确苞叶雪莲总黄酮提取工艺及其粗提物各段位抗肿瘤活性，采用正交试验优化苞叶雪莲总黄酮提取工艺，再通过组蛋白去乙酰化酶抑制试验初步评价苞叶雪莲粗提物各段位抗肿瘤活性。结果确认提取苞叶雪莲总黄酮的最佳料液比为1 g ∶25 mL，乙醇体积分数为60%，提取温度为60 ℃。苞叶雪莲粗提物的正丁醇相对组蛋白去乙酰化酶具有较好的抑制作用，抑制率高达91.34%，说明苞叶雪莲粗提物的正丁醇相可作为抗肿瘤药物的筛选。
- Abstract:
- -
参考文献/References:
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备注/Memo
- 备注/Memo:
-
收稿日期：2020-09-14
基金项目：国家自然科学基金(编号：81760783)；青海省青藏高原植物化学重点实验室创新平台建设专项(编号：2017-ZJ-Y19)。
作者简介：许地元(1996—)，男，湖北黄冈人，硕士研究生，主要从事藏药功效及成分的研究。E-mail：xudiyuan.com@qq.com。
通信作者：李海丽，教授，主要研究方向为药理学。E-mail：1164948799@qq.com。
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