[1]黄磊,郝建,郑广进,等.植物内生耙齿属真菌代谢产物及活性研究进展[J].江苏农业科学,2026,54(11):8-18.
 Huang Lei,et al.Research progress on metabolites and bioactivities of endophytic fungi from Irpex sp.[J].Jiangsu Agricultural Sciences,2026,54(11):8-18.
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植物内生耙齿属真菌代谢产物及活性研究进展()

《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第54卷
期数:
2026年第11期
页码:
8-18
栏目:
专论与综述
出版日期:
2026-06-05

文章信息/Info

Title:
Research progress on metabolites and bioactivities of endophytic fungi from Irpex sp.
作者:
黄磊1 郝建2 郑广进1 许丹妮1 赵高岗1 诸葛文凤1 黄桔1 杨涛1 潘丽琴1
1.广西民族师范学院,广西崇左 532200; 2.中国林业科学研究院热带林业实验中心,广西凭祥 532600
Author(s):
Huang Leiet al
关键词:
耙齿属代谢产物萜类呋喃衍生物抗菌抗炎抗肿瘤
Keywords:
-
分类号:
S184
DOI:
-
文献标志码:
A
摘要:
近年来,植物内生真菌与次生代谢物的关系成为研究热点。耙齿属真菌为药用真菌,其与宿主植物的共生关系及代谢产物多样性具有重要的研究价值,耙齿属内生真菌可产生萜类、呋喃衍生物及吡啶类等多种结构类型的次生代谢产物,具有抗菌、抗炎、抗氧化、抗肿瘤及神经保护等生物活性。本文结合笔者对植物内生耙齿属真菌的研究,系统论述植物耙齿属内生真菌的分类及分布特征、代谢产物的化学结构类型、主要产物骨架的生物合成机制、药理作用机制、生物活性及培养研究方法的最新进展,旨在为植物内生耙齿菌真菌代谢产物的深入研究和开发利用提供参考。
Abstract:
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参考文献/References:

[1]Zhao J,Shan T,Mou Y,et al. Plant-derived bioactive compounds produced by endophytic fungi[J]. Mini Rev Med Chem,2011,11(2):159-168.
[2]Quentin F,Lorène G,Sonia L,et al. Orchids and their mycorrhizal fungi:an insufficiently explored relationship.[J]. Mycorrhiza,2020,30(1):5-22.
[3]Pandey S S,Singh S,Babu C S V,et al. Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids[J]. Planta,2016,243(5):1097-1114.
[4]黄磊,邱仕瑜,鲁松梅,等. 金刚纂内生真菌Irpex sp.的次生代谢产物研究[J]. 宁夏大学学报(自然科学版),2024,45(1):55-59,68.
[5]Dong X M,Song X H,Dong C H. Nutritional requirements for mycelial growth of milk-white toothed mushroom,Irpex lacteus (Agaricomycetes),in submerged culture[J]. International Journal of Medicinal Mushrooms,2017,19(9):829-838.
[6]Duan X X,Xu F F,Qin D,et al. Diversity and bioactivities of fungal endophytes from Distylium chinense,a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir[J]. BMC Microbiology,2019,19(1):278-285.
[7]Noriler S,Savi D,Aluizio R,et al. Bioprospecting and structure of fungal endophyte communities found in the Brazilian biomes,Pantanal,and Cerrado[J]. Frontiers in Microbiology,2018,9:1526-1538.
[8]Santos I,Abdel-Azeem A,Mohesien M,et al. Insights into the bioprospecting of the endophytic fungi of the medicinal plant Palicourea rigida Kunth (Rubiaceae):detailed biological activities[J]. Journal of Fungi,2021,7(9):689-689.
[9]Wang L,Li S D,Cui Q,et al. Biological characteristics,domestication,and antioxidant activity of Inocutis tamaricis[J]. Acta Edulis Fungi,2023,30(1):36-44.
[10]Chen C C,Chen C Y,Wu S H,et al. Species diversity,taxonomy and multi-gene phylogeny of phlebioid clade (Phanerochaetaceae,Irpicaceae,Meruliaceae) of Polyporales[J]. Fungal Diversity,2021,111(1):337-442.
[11]Luo H Z,Jiang H,Huang X S,et al. New sesquiterpenoids from plant-associated Irpex lacteus[J]. Frontiers in Chemistry,2022,10(10):905108.
[12]Luo H Z,Jiang H,Sun B,et al. Sesquiterpenoids and furan derivatives from the Orychophragmus violaceus (L.) O.E.Schulz endophytic fungus Irpex lacteus OV38[J]. Phytochemistry,2022,194:112996.
[13]孙承通. 拟康氏木霉菌MK696749和白耙齿菌MT276332次生代谢产物及其生物活性研究[D]. 昆明:云南大学,2021:28-32.
[14]王代丽. 芽枝状枝孢霉菌(Cladosporium cladosporioides)和白囊耙齿菌(Irpex lacteus)活性代谢产物研究[D]. 昆明:云南大学,2022:31-33
[15]Fang W,Ma X W,Ablat T,et al. A comparison of polypore funga and species composition in forest ecosystems of China,North America,and Europe[J]. Forest Ecosystems,2022,4(9):100051.
[16]Xu J Y,Shi R Y,Cheng Y J,et al. Metabolomic association analysis reveals defense related secondary metabolic reprogramming in callus of Scutellaria baicalensis Georgi induced by endophytic Pseudomonas sp.2B[J]. Industrial Crops and Products,2022,187(Pt.A):115409.
[17]Duan X,Qin D,Song H,et al. Irpexlacte A-D,four new bioactive metabolites of endophytic fungus Irpex lacteus DR10-1 from the waterlogging tolerant plant Distylium chinense[J]. Phytochemistry Letters,2019,32:151- 156.
[18]Itzel N G,Guillermo M A,Silvia G H,et al. Bioprospecting of endophytic fungi from semidesert candelilla (Euphorbia antisyphilitica Zucc):Potential for extracellular enzyme production[J]. Journal of Basic Microbiology,2024,64(7):2400049.
[19]Mohamed O,Alaa A Z,Mohamed A S,et al. Diversity and bioprospecting activities of endophytic fungi associated with different Egyptian medicinal plants[J]. Scientific Reports,2025,15(1):19494.
[20]Du S,Lu J,Hu B,et al. Endophytic fungi prevent corm Rot disease and stimulate the growth and metabolism of Crocus sativus[J]. Applied Biochemistry and Microbiology,2023,59(4):503-510.
[21]Fatemeh K,Ali G,Asili J,et al. Beneficial effects of endophytic fungi inoculation on tanshinones and phenolic compounds of Salvia abrotanoides[J]. Iranian Journal of Basic Medical Sciences,2023,26(4):408-413.
[22]Ying Y M,Xu Y L,Yu H F,et al. Biotransformation of Huperzine A by Irpex lacteus-a fungal endophyte of Huperzia serrata[J]. Fitoterapia,2019,138:104341.
[23]Zhou Q,Yang X,Zhang Z,et al. New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus[J]. Fitoterapia,2018,130(7):26-30.
[24]Sharma K,Verma R,Kumar D,et al. Impact of Irpex lenis and Schizophyllum commune endophytic fungi on Perilla frutescens:enhancing nutritional uptake,phytochemicals,and antioxidant potential[J]. Microbial Cell Factories,2024,23(1):226-226.
[25]Yadav R,Vasundhara M,Rajamani T,et al. Isolation and characterization of thermostable and alkali-tolerant cellulase from litter endophytic fungus Bartalinia pondoensis[J]. Folia Microbiologica,2022,67(6):955-964.
[26]贾悦,葛安,冯利丽,等. 葛枣猕猴桃产生物碱内生真菌的筛选及鉴定[J/OL]. 分子植物育种,2023:1-11(2023-10-25)[2025-07-20]. https://link.cnki.net/urlid/46.1068.S.20231024.1507.008.
[27]王诺依,刘洪新,陈玉婵,等. 广藿香内生真菌撕裂耙齿菌A878次级代谢产物研究[J]. 中草药,2023,54(4):1017-1025.
[28]李云芳,田学军,杨光忠,等. 金刚纂的化学成分研究[J]. 华东师范大学学报(自然科学版),2008,42(3):396-399.
[29]段云凤,尹力玄,娄嘉豪,等. 金刚纂的化学成分研究[J]. 云南民族大学学报(自然科学版),2021,30(6):519-524.
[30]张婷婷,马国需,许福泉,等. 诸葛菜水溶性化学成分的研究[J]. 中国药学杂志,2014,49(24):2165-2167.
[31]Xu Z X,Li B,Tian Y,et al. Pentacyclic spermidine alkaloids with radioprotective and anti-inflammatory activities from Orychophragmus violaceus.[J]. Organic & Biomolecular Chemistry,2021,19(45):9844-9848.
[32]胡文权,高歌. 药食兼有的古蔬:诸葛菜[J]. 种子世界,2004,(7):56.
[33]杜俊蓉,白波,余彦,等. 当归挥发油研究新进展[J]. 中国中药杂志,2005,30 (18):1400-1406.
[34]冯学花,梁肖蕾. 当归化学成分与药理作用的研究进展[J]. 广州化工.2012,40 (22):16-18.
[35]毛宇,徐芳,邹云,等. 当归多糖对造血功能的影响及其机制的研究[J]. 食品研究与开发,2015,36(8):5.
[36]孙玉敏,宋福成,吴晓光,等. 当归补血汤抑制荷瘤小鼠肿瘤生长的作用[J]. 现代生物医学进展.2006.6(9):31-32+35.
[37]魏明刚,张玲,李凤玲,等. 加味当归补血汤对阿霉素肾病大鼠肾脏足细胞保护机制的研究[J]. 中国中西医结合杂志,2012,32(8):1071-1082.
[38]李云,王志伟,刘大会,王晓,周洪雷.天麻化学成分研究进展[J]. 山东科学,2016,29(4):24-29.
[39]Jang Y W,Lee J Y,Kim C J,et al. Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl.[J]. International Immunopharmacology,2010,10(2):147-154.
[40]Huang C L,Yang J M,Wang K C,et al. Gastrodia elata prevents huntingtin aggregations through activation of the adenosine A:a receptor and ubiquitin proteasome system[J]. Journal of Ethnopharmacology,2011,138 (1):162-168.
[41]Swamy M,Sinniah U. A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth.:an aromatic medicinal plant of industrial importance [J]. Molecules,2015,20(5):8521-8547.
[42]Chen J R,Xie X F,Li M T,et al. Pharmacological activities and mechanisms of action of Pogostemon cablin Benth:a review [J]. Chin Med,2021,16(1):5-5.
[43]王忠艳,于萍,陈艳秋. 白耙齿菌最佳培养基配方[J]. 食用菌学报,2013,20(3):15-17.
[44]李蒙,杜林娜,张野,等. 响应面法结合满意度函数优化白囊耙齿菌发酵培养基[J]. 中国医药工业杂志,2011,42(1):17-20.
[45]赵兴红. 白囊耙齿菌的液体发酵及其多糖抗肿瘤活性的研究[D]. 长春:吉林大学,2009:25-32.
[46]图力古尔,鲁铁,刘宇. 多孔菌科4种白腐菌培养特性[J]. 中国食用菌,2013,32(5):21-28.
[47]Shi L J,Wu Y M,Yang X Q,et al. The cocultured Nigrospora oryzae and Collectotrichum gloeosporioides,Irpex lacteus,and the plant host Dendrobium officinale bidirectionally regulate the production of phytotoxins by anti-phytopathogenic metabolites[J]. Journal of Natural Products,2020,83(5):1374-1382.
[48]Yin H Y,Yang X Q,Wang D L,et al. Antifeedant and antiphytopathogenic metabolites from co-culture of endophyte Irpex lacteus,phytopathogen Nigrospora oryzae,and entomopathogen Beauveria bassiana[J]. Fitoterapia,2021,148:104781.
[49]Chen H P,Ji Xu,Li Z H,et al. Irlactane and tremulane sesquiterpenes from the cultures of the medicinal fungus Irpex lacteus HFG1102[J]. Natural Products and Bioprospecting,2020,10(2):89-100.
[50]Tang Y,Zhao Z Z,Feng T,et al. Triterpenes with unusual modifications from the fruiting bodies of the medicinal fungus Irpex lacteus[J]. Phytochemistry,2019,162:21-28.
[51]Tang Y,Zhao Z Z,Yao J N,et al. Irpeksins A-E,1,10- seco-eburicane-type triterpenoids from the medicinal fungus Irpex lacteus and their anti-NO activity[J]. Journal of Natural Products,2018,81(10):2163-2168.
[52]Tang Y,Zhao Z Z,Li Z H,et al. Irpexoates A-D,four triterpenoids with malonyl modifications from the fruiting bodies of the medicinal fungus Irpex lacteus[J]. Natural Products and Bioprospecting,2018,8(3):171-176.
[53]Tang Y,Zhao Z Z,Hu K,et al. Irpexolidal represents a class of triterpenoid from the fruiting bodies of the medicinal fungus Irpex lacteus[J]. The Journal of Organic Chemistry,2019,84(4):1845-1852.
[54]Wang M,Li Z H,Liu J K,et al. Furan derivatives and polyketides from the fungus Irpex lacteus[J]. Natural Products and Bioprospecting,2020,31(1):1-8.
[55]Chen Q,Wang M,Yi X W,et al. Two new pyridine derivatives and two new furan derivatives from Irpex lacteus[J]. Natural Product Research,2021,36(15):1-7.
[56]Elaine J F,Mohamed R,Khoo H,et al. Analysis of chemical constituents,antimicrobial and anticancer activities of dichloromethane extracts of Sordariomycetes sp.endophytic fungi isolated from Strobilanthes crispus[J]. World Journal of Microbiology & Biotechnology,2016,33(1):5-12.
[57]Ahmed T,Abbott G,Young L,et al. Metabolomic-guided isolation of bioactive natural products from Curvularia sp.,an Endophytic Fungus of Terminalia laxiflora[J]. Planta Medica,2017,84(3):182-190.
[58]Liu H C,Kong F D,Zhu Z X,et al. Hypolipidemic sesquiterpenoids with diverse structural skeletons from the medicinal fungus Irpex lacteus[J]. Phytochemistry,2024,232:114362.
[59]章唐桀,朱震鑫,严静,等. 白耙齿菌次级代谢产物及降脂活性研究[J]. 中国药学杂志,2025,60(8):793-800.
[60]Yu G H,Shang Z M,Li W T,et al. Pyridine derivatives and furan derivatives identified from the medicinal mushroom Irpex lacteus SY1002[J]. Chemistry & Biodiversity,2025,22(6):202403124.
[61]罗怀志. 二月兰内生真菌Irpex lacteus的化学成分及其群体感应抑制活性研究[D]. 南京:南京理工大学,2022:30-43
[62]Gao Y,Feng Y Y,Chang Y Y,et al. Biotransformation of ginsenoside Rb1 to ginsenoside Rd and 7 rare ginsenosides using Irpex lacteus with HPLC-HRMS/MS identification[J]. ACS Omega,2024,9(21):22744-22753.
[63]Thakur A,Thakur K,Kumar A,et al. Endophyte-based fungal elicitors for enhanced production of valepotriates and sesquiterpenoids in leaf cell suspension cultures of Valeriana jatamansi Jones[J]. Journal of Applied Microbiology,2024,135:242.
[64]Li J H,Li X H,Da Y B,et al. Sustainable environmental remediation via biomimetic multifunctional lignocellulosic nano-framework[J]. Nature Communications,2022,13(1):43-68.
[65]Li G,Kusari S,Golz C,et al. Epigenetic modulation of endophytic Eupenicillium sp. LG41 by a histone deacetylase inhibitor for production of decalin-containing compounds[J]. Journal of Natural Products,2017,80(4):983-988.

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备注/Memo

备注/Memo:
收稿日期:2025-05-30
基金项目:国家重点研发计划(编号:2024YFD2200101);广西林业科技推广项目(编号:桂林科研[2022]第2号);广西民族师范学院校级科研项目(编号:2024YB078);广西民族师范学院校级人才启动基金(编号:2023XBNGCC03)。
作者简介:黄磊(1996—),男,广东茂名人,硕士,从事植物内生真菌代谢产物研究。E-mail:1334465102@qq.com。
通信作者:潘丽琴,博士,讲师,主要从事林木繁育与资源利用研究。E-mail:465545283@qq.com。
更新日期/Last Update: 2026-06-05