[1]陈圆,张龙,王莹,等.金雀异黄素壳聚糖纳米粒子体外释放动力学研究[J].江苏农业科学,2015,43(11):280-282.
　Chen Yuan,et al.Study on release kinetics of genistein chitosan nanoparticles in vitro[J].Jiangsu Agricultural Sciences,2015,43(11):280-282.
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金雀异黄素壳聚糖纳米粒子体外释放动力学研究()

《江苏农业科学》[ISSN:1002-1302/CN:32-1214/S]

卷:
第43卷
期数:
2015年11期
页码:
280-282
栏目:
畜牧兽医
出版日期:
2015-11-25

文章信息/Info

Title:
Study on release kinetics of genistein chitosan nanoparticles in vitro
作者:
陈圆1;  张龙1; 2;  王莹2;  刘天晴2
1. 江苏农牧科技职业学院，江苏泰州 225300；2.扬州大学化学化工学院，江苏扬州 225002
Author(s):
Chen Yuan; et al
关键词:
金雀异黄素; 壳聚糖; 纳米粒子; 释放动力学; 释放速率常数
Keywords:
-
分类号:
R944
DOI:
-
文献标志码:
A
摘要:
采用透析法考察不同介质pH值和离子浓度对金雀异黄素壳聚糖纳米粒子体外释放的影响，并采用零级动力学方程、一级动力学方程、Higuchi方程和双相动力学方程，对纳米粒子的体外释放动力学进行探讨。结果表明，该纳米粒子的体外释放与介质pH值和离子浓度有关，随着介质pH值增大，纳米粒子中药物释放量减少；随着介质中离子浓度的增大，纳米粒子的释药量相应增大。释药数据拟合显示，金雀异黄素对照品在含40%乙醇的磷酸盐缓冲液(PBS)中的体外释放符合零级动力学方程，呈线性释放，释放速率常数为0.122 min-1；而该纳米粒子在释放介质中的释药行为符合双相动力学方程，先快速释药，后缓慢释放，释放速率常数分别为0.110、0.032 min-1。
Abstract:
-

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期：2014-12-20
基金项目：江苏省研究生科技创新计划(编号：CXZZ13_0893)；江苏省2012年度“青蓝工程”资助项目。
作者简介：陈圆(1981—)，女，江苏泰兴人，博士，副教授，研究方向为药物新剂型。E-mail：jstzchenyuan@163.com。
通信作者：张龙(1966—)，男，江苏靖江人，教授，研究方向为药物新剂型，E-mail：longz98@163.com；刘天晴(1959—)，男，江苏淮安人，博士，教授，研究方向为胶体与界面化学，E
更新日期/Last Update: 2015-11-25